Extracts from New Zealand spinach (Tetragonia tetragonioides) conferring anti-obesity effects
14. Dezember 2016 (online)
Compared to anti-obesity drugs such as orlistat or sibutramine which are reported to have side-effects including raising blood pressure, headache or insomnia, some natural products have been empirically proven to have valuable anti-obesity potential. Based on preliminary research implementation, we designed to test whether ethanol and water-soluble extracts (HFD-TTK) of New Zealand spinach prevent obesity by evaluating weight change, feeding efficacy, tissue fat reduction, gene expression, and histological comparison. Compared to high-fat diet negative control mouse (HRD-NC), the weight was reduced by 9.7% and 16.3% with positive control Xenical (15.6 mg/ml, HFD-XNC) and HFD-TTK (200 mg/kg) applications, respectively. Feeding efficacy rate was reduced by 13.6% in HFD-XNC, and 9.6% in HFD-TTK mice. Fat reduction in the abdominal tissue, epididymal and kidney adipose tissues was evident both in HFD-XNC and HFD-TTK-fed mice compared to high-fat diet control. Similarly HFD-XNC and HFD-TTK-fed mice showed significantly reduced serum triglyceride, LDL-cholesterol, and free fatty acid contents, along with no kidney and liver toxicity, enhanced serum adiponectin protein and lowered serum IGF-1 protein. These features were partly explained by lowed expression of adipogenesis genes and upregulated activation of AMP-kinase metabolism, which was also proven by histological observation of lipid mass.
Acknowledgements: This study was supported by the INNOPOLIS Foundation grant funded by the Korea government (Ministry of Science, ICT & Future Planning) (A2103DD018).
Keywords: Herbal extract, New Zealand spinach, obesity mouse model, lipolytic gene, AMP-kinase, histological comparison.
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