Planta Med 2016; 82(S 01): S1-S381
DOI: 10.1055/s-0036-1596738
Abstracts
Georg Thieme Verlag KG Stuttgart · New York

Secondary metabolites from the fungus Porodaedalea pini

SS Yang
1   Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsuing 807, Taiwan
,
HY Chan
2   Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, Taiwan
,
SY Hsieh
2   Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, Taiwan
,
GF Yuan
2   Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, Taiwan
,
SL Wong
1   Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsuing 807, Taiwan
,
CH Lin
3   School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsuing 807, Taiwan
,
MJ Cheng
2   Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, Taiwan
,
IS Chen
1   Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsuing 807, Taiwan
3   School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsuing 807, Taiwan
4   Research Center for Natural Products and Drug Development, Kaohsiung Medical University, Kaohsuing 807, Taiwan
,
HS Chang
1   Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsuing 807, Taiwan
3   School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsuing 807, Taiwan
4   Research Center for Natural Products and Drug Development, Kaohsiung Medical University, Kaohsuing 807, Taiwan
5   Center for Infectious Disease and Cancer Research (CICAR), Kaohsiung Medical University, Kaohsiung 807, Taiwan
› Author Affiliations
Further Information

Publication History

Publication Date:
14 December 2016 (online)

 

A fungus, Porodaedalea pini (Brot.) Murrill (Phellinus pini) (Hymenochaetaceae), which causes tree diseases commonly known as “red ring rot” or “white speck”, is an important forest disturbance agent and plays a key role in habitat formation for several forest animals. Previous research revealed the diverse constituents of P. pini, including amines, amino acids, aromatic compounds, ceramides, diterpenoids, lignans, polyketides, polysaccharides, quinones, and steroids. P. pini was processed through liquid-state fermentation, and its liquid fermentate showed androgen regulation (AR) activity based on a preliminary screening.

The liquid fermentate was partitioned and afforded ethyl acetate, n-butanol and water-soluble extracts. Bioassay-guided fractionation of the active ethyl acetate-soluble layer of the liquid fermentate of P. pini led to the isolation of two new aromatic compounds, piniphenol A (1) and piniphenol B (2), one aromatic compound, (R)-(+)-4-hydroxyphenyloxirane (3) [1] that was isolated from nature for the first time along with five known aromatic compounds, 4-vinylphenol (4), 4-hydroxybenzaldehyde (5), 2-methoxy-2-(4'-hydroxyphenyl)ethanol (6), 2,3-dihydroxypropyl acetate (7), and phenol (8). The structures of these compounds were elucidated by spectral analysis. The isolation of the active fractions is still in progress and the isolates are further evaluated with regard to androgen regulation activity.

Acknowledgements: This work was supported by Food Industry Research and Development Institute (FIRDI), Kaohsiung Medical University Research Foundation (KMU-Q104011).

Keywords: Porodaedalea pini, Hymenochaetaceae, fungus, androgen regulation activity.

References:

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