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Am J Perinatol 2017; 34(05): 419-427
DOI: 10.1055/s-0036-1592348
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Evaluation of Cerebral Oxygenation in Neonates with Sepsis with Near-Infrared Spectroscopy

Dimitrios Rallis
1   2nd NICU and Neonatology Department, General Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece
,
Paraskevi Karagianni
1   2nd NICU and Neonatology Department, General Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece
,
Eleni Milona
1   2nd NICU and Neonatology Department, General Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece
,
Paraskevi Pratsiou
1   2nd NICU and Neonatology Department, General Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece
,
Nikolaos Nikolaidis
1   2nd NICU and Neonatology Department, General Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece
,
Christos Tsakalidis
1   2nd NICU and Neonatology Department, General Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece
› Author Affiliations
Further Information

Publication History

01 April 2016

02 August 2016

Publication Date:
14 September 2016 (online)

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Abstract

Objective Neonates with sepsis have increased risk of cerebral injury. Our aim was to evaluate cerebral oxygenation in septic neonates using near-infrared spectroscopy.

Study Design A prospective study was designed enrolling neonates with sepsis, as defined by the International Consensus Conference of Pediatric Sepsis criteria and matched controls. Three cerebral half–hourly measurements were performed during the first, third, and seventh day of the episode and the values of tissue oxygenation index (TOI) and fractional tissue oxygen extraction (FTOE) were compared between the two groups.

Result The study population consisted of 50 septic and 44 control neonates with similar characteristics. No differences on TOI and FTOE were recorded in the first and third day. However, on the seventh day, septic neonates had significantly decreased oxygenation (62.7 ± 7 vs. 71.4 ± 4.4%, p < 0.001) and increased oxygen extraction (0.35 ± 0.07 vs. 0.27 ± 0.05, p < 0.001), irrespectively of the severity of the infection.

Conclusion Although septic neonates have normal cerebral oxygenation in the first and third day of the sepsis, they present decreased cerebral oxygenation in the seventh day independently of the infection severity.

Keywords

near-infrared spectroscopy - neonate - cerebral oxygenation - sepsis

Funding

None.


 

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