Amer J Perinatol 2017; 34(4): 397-402
DOI: 10.1055/s-0036-1592131
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Recurrence of Preterm Delivery in Women with a Family History of Preterm Delivery

Yehonatan Sherf1, 2, Eyal Sheiner3, Ilana Shoham Vardi2, Ruslan Sergienko2, Jamie Klein4, Natalya Bilenko2, 5
  • 1The Joyce and Irving Goldman Medical School, Faculty of Health Sciences, Soroka University Medical Center, Ben Gurion University of the Negev, Be'er-Sheva, Israel
  • 2Department of Public Health, Faculty of Health Sciences, Ben Gurion University of the Negev, Be'er-Sheva, Israel
  • 3Department of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben Gurion University of the Negev, Be'er-Sheva, Israel
  • 4The Medical School for International Health in Affiliation with Columbia University, Faculty of Health Sciences, Ben Gurion University of the Negev, Be'er-Sheva, Israel
  • 5Medical Office of Ashkelon District, Ministry of Health, Israel
Further Information

Publication History

03 April 2016

27 July 2016

Publication Date:
08 September 2016 (eFirst)

Abstract

Objective This study aims to evaluate the role of a family history of preterm delivery on the risk of preterm delivery in the next generation.

Study Design A retrospective population-based study was conducted. Perinatal information was gathered from 2,303 familial triads, composed of mothers (F1), daughters (F2), and children (F3). All births occurred in the same regional medical center between the years 1991 and 2013. Statistical analysis using logistic regression was performed to define the risk of F2 delivering a preterm baby (F3) if she was born preterm herself, and then to define the risk of F2 delivering preterm if her mother (F1) gave birth preterm during any of her birthing events.

Results The risk for preterm delivery of the F2 parturient was 34% greater if their mother (F1) at any of her births had delivered preterm, controlling for parity, maternal age at delivery, and preeclampsia (adjusted odds ratio: 1.34, 95% confidence interval: −1.01 to 1.77; p = 0.042).

Conclusion The family history of preterm delivery is an independent risk factor for preterm delivery. The family history includes the mother as well as one of the mother's sisters (F2 generation) being born preterm.

Note

The abstract was presented at the SMFM 2016 Annual Meeting, February 01–06, The ATL, Control ID: 966.