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CC BY-ND-NC 4.0 · SynOpen 2017; 01(01): 0125-0128
DOI: 10.1055/s-0036-1591507
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An Expeditious, Green and Protecting-Group-Free Synthesis of a Potent Secondary Metabolite Calebin-A and Its Analogues

Anju Majeed
a   Sami Labs Ltd., 19/1 & 19/2, I Main, II Phase, Peenya Industrial Area, Bangalore-560058, India
,
Kalyanam Nagabhushanam  *
b   Sabinsa Corporation, 20 Lake Drive, East Windsor, NJ 08520, USA   eMail: kalyanam@sabinsa.com
,
Muhammed Majeed
a   Sami Labs Ltd., 19/1 & 19/2, I Main, II Phase, Peenya Industrial Area, Bangalore-560058, India
b   Sabinsa Corporation, 20 Lake Drive, East Windsor, NJ 08520, USA   eMail: kalyanam@sabinsa.com
,
Samuel Manoharan Thomas
a   Sami Labs Ltd., 19/1 & 19/2, I Main, II Phase, Peenya Industrial Area, Bangalore-560058, India
,
Nooruddin Thajuddin
c   Department of Microbiology, Faculty of Science, Engineering & Technology, Bharathidasan University, Thiruchirapalli-620024, Tamil Nadu, India
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Publikationsverlauf

Received: 18. August 2017

Accepted after revision: 04. Oktober 2017

Publikationsdatum:
20. Oktober 2017 (online)

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Erratum zu diesem Artikel:

An Expeditious, Green and Protecting-Group-Free Synthesis of a Potent Secondary Metabolite Calebin-A and Its AnaloguesSynOpen 2017; 01(01): e2-e2
DOI: 10.1055/s-0036-1589522

Abstract

The synthesis of Calebin-A (10a) and analogues (10b–d), which are minor but pharmacologically active components (<0.01% of the oleoresin) of curcuma longa, is described. This flexible synthesis is achieved under near neutral conditions in water/solvent biphasic medium at room temperature without involving any protecting groups.

Key words

Calebin-A - Curcuma longa - ferulic acid ester - phase-transfer catalyst (PTC) - green synthesis
 

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