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CC BY ND NC 4.0 · SynOpen 2017; 01(01): 0147-0155
DOI: 10.1055/s-0036-1590963
DOI: 10.1055/s-0036-1590963
paper
Synthesis of N-Pyridin-2-ylmethyl and N-Quinolin-2-ylmethyl Substituted Ethane-1,2-diamines
This project was financially supported by the National Natural Science Funds of China (Grant No. 81272833) and Guangdong Science Foundation (Grant No. 2016A030313676).
Weitere Informationen
Publikationsverlauf
Received: 20. September 2017
Accepted after revision: 26. Oktober 2017
Publikationsdatum:
23. November 2017 (online)
§ The authors contributed equally to this work
Abstract
Two N-(2-(bis(pyridin-2-ylmethyl)amino)ethyl)quinoline-2-carboxamides and two N-(2-(bis(quinolin-2-ylmethyl)amino)ethyl)quinoline-2-carboxamides have been synthesized. These structures contain five nitrogen atoms that can form coordinate bonds with metal ions such as Mn(II) and Fe(II). An additional coordinating bond can be formed between the metal ion and a neutral molecule of nitric oxide (NO). The resultant complexes are potentially useful agents for targeted delivery of NO to in vivo biological sites such as tumors, where the NO is released upon irradiation with long-wavelength light. Initial work involving the synthesis and characterization of these analogues is reported here.
Supporting Information
- Supporting information of 1H NMR and 13C NMR spectra as well as some UV and fluorescence
measurement for this article is available online at https://doi.org/10.1055/s-0036-1590963.
- Supporting Information
-
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