CC BY ND NC 4.0 · SynOpen 2017; 01(01): 0147-0155
DOI: 10.1055/s-0036-1590963
paper
Copyright with the author

Synthesis of N-Pyridin-2-ylmethyl and N-Quinolin-2-ylmethyl ­Substituted Ethane-1,2-diamines

Yi-Qiu Yang
School of Pharmacy, Guangdong Medical University, 1 Xincheng Ave, Songshan Lake Technology Park, Dongguan, 523808, P. R. of China   Email: yshuang@gdmu.edu.cn
,
Long-Zhi Ke
Laboratory of Urology, Guangdong Medical University, ­Zhanjiang 524001, P. R. of China   Email: jianjunliulab@163.com
,
Gui-Fei Wang
School of Pharmacy, Guangdong Medical University, 1 Xincheng Ave, Songshan Lake Technology Park, Dongguan, 523808, P. R. of China   Email: yshuang@gdmu.edu.cn
,
Shu-Yong Song
School of Pharmacy, Guangdong Medical University, 1 Xincheng Ave, Songshan Lake Technology Park, Dongguan, 523808, P. R. of China   Email: yshuang@gdmu.edu.cn
,
Ming-Ning Qiu
Laboratory of Urology, Guangdong Medical University, ­Zhanjiang 524001, P. R. of China   Email: jianjunliulab@163.com
,
Jian-Jun Liu*
Laboratory of Urology, Guangdong Medical University, ­Zhanjiang 524001, P. R. of China   Email: jianjunliulab@163.com
,
Yun-Sheng Huang*
School of Pharmacy, Guangdong Medical University, 1 Xincheng Ave, Songshan Lake Technology Park, Dongguan, 523808, P. R. of China   Email: yshuang@gdmu.edu.cn
› Author Affiliations
This project was financially supported by the National Natural ­Science Funds of China (Grant No. 81272833) and Guangdong Science Foundation (Grant No. 2016A030313676).
Further Information

Publication History

Received: 20 September 2017

Accepted after revision: 26 October 2017

Publication Date:
23 November 2017 (online)

§ The authors contributed equally to this work

Abstract

Two N-(2-(bis(pyridin-2-ylmethyl)amino)ethyl)quinoline-2-carboxamides and two N-(2-(bis(quinolin-2-ylmethyl)amino)ethyl)quinoline-2-carboxamides have been synthesized. These structures contain five nitrogen atoms that can form coordinate bonds with metal ions such as Mn(II) and Fe(II). An additional coordinating bond can be formed between the metal ion and a neutral molecule of nitric oxide (NO). The resultant complexes are potentially useful agents for targeted delivery of NO to in vivo biological sites such as tumors, where the NO is released upon irradiation with long-wavelength light. Initial work involving the synthesis and characterization of these analogues is reported here.

Supporting Information

 
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