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CC BY ND NC 4.0 · SynOpen 2017; 01(01): 0050-0058
DOI: 10.1055/s-0036-1590800
DOI: 10.1055/s-0036-1590800
paper
Efficient Synthesis of Pyrazinoic Acid Hybrid Conjugates
Autoren
Weitere Informationen
Publikationsverlauf
Received: 05. April 2017
Accepted after revision: 31. Mai 2017
Publikationsdatum:
06. Juli 2017 (online)
Abstract
Benzotriazole-activated pyrazinoic acid was utilized as a versatile building block for the efficient and convenient synthesis of novel hybrid conjugates of pyrazinoic acid with secondary amines via amino acid linkers in high yields.
Key words
pyrazinamide - pyrazinoic acid - secondary amines - amino acids - benzotriazole methodology - antituberculosisSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1590800.
- Supporting Information (PDF) (opens in new window)
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References
- 1 Mitchison DA. Tubercle 1985; 66: 219
- 2 Joshi RR. Barchha A. Khedkar VM. Pissurlenkar RR. S. Sarkar S. Sarkar D. Joshi RR. Joshi RA. Shah AK. Coutinho EC. Chem. Biol. Drug Des. 2015; 85: 201
- 3 Rivers EC. R. Mancera L. Drug Discovery Today 2008; 13: 1090
- 4 World Health Organization. Global Tuberculosis, Report 2013. WHO/HTM/TB/ 2013, 11.
- 5 Goletti D. Weissman D. Jackson RW. Graham NM. Vlahov D. Klein RS. Munsiff SS. L’Ortona L. Cauda R. Fauci AS. J. Immunol. 1996; 157: 1271
- 6 Ma Z. Ginsberg AM. Spigelman M. Antimycobacterium agents, In Comprehensive Medicinal Chemistry II . Taylor JB. Triggle DJ. Elsevier; Oxford: 2006. Vol. 7, 699
- 7 Kremer L. Besra GS. Expert Opin. Invest. Drugs 2002; 11: 1033
- 8 World Health Organization (WHO), WHO Report 2010: Global Tuberculosis Control, 2010.
- 9 Zhang Y. Mitchison D. Int. J. Tuberc. Lung Dis. 2003; 7: 6
- 10 Van den Boogaard J. Kibiki GS. Kisanga ER. Boeree MJ. Aarnoutse RE. Antimicrob. Agents Chemother. 2009; 53: 849
- 11 Reddy VM. Nadadhur G. Daneluzzi D. Dimova V. Gangadharam PR. Antimicrob. Agents Chemother. 1995; 39: 2320
- 12 Chitre TS. Asgaonkar KD. Miniyar PB. Dharme AB. Arkile MA. Yeware A. Sarkar D. Khedkar VM. Jha PC. Bioorg. Med. Chem. Lett. 2016; 26: 2224
- 13 Jardosh HH. Patel MP. Eur. J. Med. Chem. 2013; 65: 348
- 14 Saha R. Alam MM. Akhter M. RSC Adv. 2015; 5: 12807
- 15 Simoes MF. Valente E. Gomez MJ. R. Anes E. Constantino L. Eur. J. Pharm. Sci. 2009; 37: 257
- 16 Mohamed T. Zhao X. Habib LK. Yang J. Rao PP. N. Bioorg. Med. Chem. 2011; 19: 2269
- 17 Panda SS. Bajaj K. Meyers MJ. Sverdrup FM. Katritzky AR. Org. Biomol. Chem. 2012; 10: 8985
- 18 Ibrahim MA. Panda SS. Birs AS. Serrano JC. Gonzalez CF. Alamry KA. Katritzky AR. Bioorg. Med. Chem. Lett. 2014; 24: 1856
- 19 Panda SS. Naumov RN. Asiri AM. Katritzky AR. Synthesis 2014; 46: 1511
- 20 Panda SS. Liaqat S. Girgis AS. Samir A. Hall CD. Katritzky AR. Bioorg. Med. Chem. Lett. 2015; 25: 3816
- 21 Panda SS. Detistov OS. Girgis AS. Mohapatra PP. Samir A. Katritzky AR. Bioorg. Med. Chem. Lett. 2016; 26: 2198
- 22 Panda SS. Hall CD. Scriven E. Katritzky AR. Aldrichimica Acta 2013; 46: 43