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CC BY-ND-NC 4.0 · SynOpen 2017; 01(01): 0050-0058
DOI: 10.1055/s-0036-1590800
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Efficient Synthesis of Pyrazinoic Acid Hybrid Conjugates

Siva S. Panda  *
a   Department of Chemistry & Physics, Augusta University, Augusta, GA 30912, USA
,
Abdullah M. Asiri
b   Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, 21589, Saudi Arabia
,
Mohamed Elagawany
c   Department of Pharmaceutical Chemistry, faculty of pharmacy, Damanhour University, Damanhour, Egypt   Email: sspanda12@gmail.com   Email: sipanda@augusta.edu
,
Devan D. Buchanan
a   Department of Chemistry & Physics, Augusta University, Augusta, GA 30912, USA
,
Behrad Torkian
a   Department of Chemistry & Physics, Augusta University, Augusta, GA 30912, USA
,
Keerthana Bathala
a   Department of Chemistry & Physics, Augusta University, Augusta, GA 30912, USA
,
Sean J. Thomas
a   Department of Chemistry & Physics, Augusta University, Augusta, GA 30912, USA
,
Jason E. Capito
a   Department of Chemistry & Physics, Augusta University, Augusta, GA 30912, USA
,
Muhammad N. Arshad
b   Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, 21589, Saudi Arabia
,
Abeer N. Al-Romaizan
b   Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, 21589, Saudi Arabia
› Author Affiliations
Further Information

Publication History

Received: 05 April 2017

Accepted after revision: 31 May 2017

Publication Date:
06 July 2017 (online)

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Abstract

Benzotriazole-activated pyrazinoic acid was utilized as a versatile building block for the efficient and convenient synthesis of novel hybrid conjugates of pyrazinoic acid with secondary amines via amino acid linkers in high yields.

Key words

pyrazinamide - pyrazinoic acid - secondary amines - amino acids - benzotriazole methodology - antituberculosis

Supporting Information

    Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1590800.
  • Supporting Information
 

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