Iridium-Catalyzed Intramolecular Oxidative Cyclization of Alkenyl Amides and Alkenoic Acids

Published as part of the Special Topic Modern Cyclization Strategies in Synthesis

Abstract

An iridium/dppf complex efficiently catalyzed the oxidative cyclization of N-sulfonyl alkenyl amides and alkenoic acids. Electron-deficien­t alkenes were effective as sacrificial hydrogen acceptors. High selectivity of the oxidative cyclization over the competing addition reaction has been realized by the use of NaI as an additive.

Key words

iridium - oxidative functionalization - alkenes - amides - carboxylic acids

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• 1 Present Address: Department of Chemistry, Graduate School of Science, Osaka City University, 3-3-138 Sugimoto Sumiyoshi-ku, Osaka 558-8585, Japan.

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