Recent Developments in the Direct Synthesis of Unprotected Primary­ Amines

Luca Legnani; Benjamin N. Bhawal; Bill Morandi

doi:10.1055/s-0036-1588371

Synthesis, Table of Contents

Synthesis 2017; 49(04): 776-789
DOI: 10.1055/s-0036-1588371

short review

Recent Developments in the Direct Synthesis of Unprotected Primary Amines

Luca Legnani

Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany Email: morandi@kofo.mpg.de

,

Benjamin N. Bhawal

Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany Email: morandi@kofo.mpg.de

,

Bill Morandi*

Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany Email: morandi@kofo.mpg.de

› Author Affiliations

Abstract

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Abstract

A large number of reports describe the formation of the fundamental C–N bond in homogeneous catalysis. Among them, only a few are able to introduce the unprotected amino group, despite the appealing insertion of this key functional group. Recently, a broad range of methods have been reported that enable direct access to the primary amine using either ammonia or other nitrogen sources. In this short review, we illustrate the progress achieved in this field.

1 Introduction

2 Hydroamination

3 Reductive Amination

4 Dehydrogenative Coupling with Alcohols

5 Amination of Aryl Halides and Boronates

6 Allylic Amination

7 C–H Amination

8 Aminofunctionalization

9 Conclusions

Key words

amine - aniline - aziridine - amino alcohols - unprotected - protecting group free synthesis - homogeneous catalysis

Full Text

References

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Recent Developments in the Direct Synthesis of Unprotected Primary­ Amines

Recent Developments in the Direct Synthesis of Unprotected Primary Amines