Journal of Pediatric Biochemistry 2013; 03(03): 123-128
DOI: 10.1055/s-0036-1586439
Review Article
Georg Thieme Verlag KG Stuttgart – New York

Antioxidants: A review

Ana B. López-Jaén
a   Department of Pediatrics, Obstetrics and Gynecology, University of Valencia, Valencia, Spain
,
Victoria Valls-Bellésa
a   Department of Pediatrics, Obstetrics and Gynecology, University of Valencia, Valencia, Spain
,
Pilar Codoñer-Franch
a   Department of Pediatrics, Obstetrics and Gynecology, University of Valencia, Valencia, Spain
b   Department of Pediatrics, Dr. Peset University Hospital, Valencia, Spain
› Author Affiliations

Subject Editor:
Further Information

Publication History

01 January 2013

11 May 2013

Publication Date:
01 August 2016 (online)

Abstract

Oxidative stress is defined as an imbalance between free radical production and antioxidant defense in favor of the first. Free radicals can exert negative effects on biomolecules and metabolic reactions that results in cellular damage which may be involved in aging processes and degenerative pathologies. To limit the harmful effects of free radicals, the organism has developed a series of antioxidant defense systems in order to protect themselves. These systems give to the free radicals elimination or its transformation into stable molecules. The antioxidant defense system consists on cellular enzymatic antioxidants such as superoxide dismutase, catalase and glutathione peroxidase and non-enzymatic antioxidants either endogenous (glutathione) or exogenous (vitamin E, vitamin C, flavonoids, carotenoids) between others.