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Journal of Pediatric Biochemistry 2015; 05(03): 094-097
DOI: 10.1055/s-0036-1571831
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Determination of Relationship between Infection and Serum Levels of Prohepcidin in Pediatric Patients before and after Bone Marrow Transplantation

Bahar Göker
1   Department of Biochemistry, Marmara University, Istanbul, Turkey
,
Meral Akbıyık
2   Department of Oral and Maxillofacial Surgery, Marmara University, Istanbul, Turkey
,
Onur Gönül
2   Department of Oral and Maxillofacial Surgery, Marmara University, Istanbul, Turkey
,
Çağrı Güleç
3   Division of Hematology/Oncology Unit of Bone Marrow Transplantation, Department of Pediatrics, Istanbul University, Istanbul, Turkey
,
Sema Anak
3   Division of Hematology/Oncology Unit of Bone Marrow Transplantation, Department of Pediatrics, Istanbul University, Istanbul, Turkey
› Author Affiliations
Further Information

Publication History

09 February 2015

08 April 2015

Publication Date:
28 January 2016 (online)

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Abstract

Since the immune system is suppressed before bone marrow transplantation (BMT), severe infections might arise. This clinical article considers the role of prohepcidin, in addition to interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in infections occurring after BMT. Serum prohepcidin, IL-6, TNF-α, and C-reactive protein (CRP) levels were measured in 10 pediatric BMT patients by enzyme-linked immunosorbent assay before and after BMT. The results were evaluated statistically. As a result of the analysis, it was observed that there was a significant correlation between serum prohepcidin and IL-6, TNF-α, and CRP levels in the pretransplantation, posttransplantation, and discharge periods of the patients. The relationship between CRP levels and prohepcidin levels suggests that the serum prohepcidin level might be an important parameter for transplantation patients in consideration of infection. Verification of these results from future studies may confirm the clinical importance of hepcidin.

Keywords

bone marrow transplantation - hepcidin - prohepcidin

Note

This study was sponsored by the Scientific Research Projects Unit of Marmara University (Project No: SAG-C-YLP-070808–0193).


 

  • References

  • 1 Armitage JO. Bone marrow transplantation. N Engl J Med 1994; 330 (12) 827-838
    CrossrefPubMedGoogle Scholar
  • 2 Arai S, Klingemann HG. Hematopoietic stem cell transplantation: bone marrow vs. mobilized peripheral blood. Arch Med Res 2003; 34 (6) 545-553
    CrossrefPubMedGoogle Scholar
  • 3 Ferrero-Miliani L, Nielsen OH, Andersen PS, Girardin SE. Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1β generation. Clin Exp Immunol 2007; 147 (2) 227-235
    PubMedGoogle Scholar
  • 4 Leather HL, Wingard JR. Infections following hematopoietic stem cell transplantation. Infect Dis Clin North Am 2001; 15 (2) 483-520
    CrossrefPubMedGoogle Scholar
  • 5 Kemna EH, Tjalsma H, Willems HL, Swinkels DW. Hepcidin: from discovery to differential diagnosis. Haematologica 2008; 93 (1) 90-97
    CrossrefPubMedGoogle Scholar
  • 6 Ganz T. Hepcidin and its role in regulating systemic iron metabolism. Hematology (Am Soc Hematol Educ Program) 2006; 507: 29-35 , 507
    PubMedGoogle Scholar
  • 7 Güneri İ, Özmen D, Bayındır O. Cytokines. Turkiye Klinikleri. J Med Sci 1997; 17: 65-74
    PubMedGoogle Scholar
  • 8 Ng PC, Cheng SH, Chui KM , et al. Diagnosis of late onset neonatal sepsis with cytokines, adhesion molecule, and C-reactive protein in preterm very low birthweight infants. Arch Dis Child Fetal Neonatal Ed 1997; 77 (3) F221-F227
    CrossrefPubMedGoogle Scholar
  • 9 Tanaka J, Imamura M, Kasai M , et al. Cytokine gene expression in the mixed lymphocyte culture in allogenic bone marrow transplants as a predictive method for transplantation-related complications. Br J Haematol 1994; 87 (2) 415-418
    CrossrefPubMedGoogle Scholar
  • 10 Chasty RC, Lamb WR, Gallati H, Roberts TE, Brenchley PEC, Yin JA. Serum cytokine levels in patients undergoing bone marrow transplantation. Bone Marrow Transplant 1993; 12 (4) 331-336
    PubMedGoogle Scholar
  • 11 Holler E, Kolb HJ, Möller A , et al. Increased serum levels of tumor necrosis factor alpha precede major complications of bone marrow transplantation. Blood 1990; 75 (4) 1011-1016
    PubMedGoogle Scholar