Semin Respir Crit Care Med 2016; 37(01): 136-142
DOI: 10.1055/s-0035-1570367
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Early Psychological Therapy in Critical Illness

Lioudmila V. Karnatovskaia
1   Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota
,
Kemuel L. Philbrick
2   Department of Psychiatry, Mayo Clinic, Rochester, Minnesota
,
Ann M. Parker
3   Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
4   Outcomes after Critical Illness and Surgery (OACIS) Group, Johns Hopkins University School of Medicine, Baltimore, Maryland
,
Dale M. Needham
3   Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
4   Outcomes after Critical Illness and Surgery (OACIS) Group, Johns Hopkins University School of Medicine, Baltimore, Maryland
5   Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, Maryland
› Author Affiliations
Further Information

Publication History

Publication Date:
28 January 2016 (online)

Abstract

Survivors of critical illness often experience long-lasting impairments in mental, cognitive, and physical functioning. Acute stress reactions and delusional memories appear to play an important role in psychological morbidity following critical illness, and few interventions exist to address these symptoms. This review elucidates acute psychological stressors experienced by the critically ill. The effects of psychological stress and state of mind on disease are discussed using examples from the non–intensive care unit (ICU) literature, including a review of placebo and nocebo effects. After reviewing the effect of the mind on both psychological and physiological outcomes, we then focus on the role of memories—including their malleable nature and the consequences of false memories. Memory may play a role in the genesis of subsequent psychological trauma. Traumatic memories may begin forming even before the patient arrives in the ICU and during their state of unconsciousness in the ICU. Hence, practical interventions for redirecting patients' thoughts, such as positive suggestion techniques and actively involving patients in the treatment process as early as possible, are worthy of further investigation.

 
  • References

  • 1 Iwashyna TJ, Cooke CR, Wunsch H, Kahn JM. Population burden of long-term survivorship after severe sepsis in older Americans. J Am Geriatr Soc 2012; 60 (6) 1070-1077
  • 2 Esteban A, Frutos-Vivar F, Muriel A , et al. Evolution of mortality over time in patients receiving mechanical ventilation. Am J Respir Crit Care Med 2013; 188 (2) 220-230
  • 3 Needham DM, Davidson J, Cohen H , et al. Improving long-term outcomes after discharge from intensive care unit: report from a stakeholders' conference. Crit Care Med 2012; 40 (2) 502-509
  • 4 Pandharipande PP, Girard TD, Jackson JC , et al; BRAIN-ICU Study Investigators. Long-term cognitive impairment after critical illness. N Engl J Med 2013; 369 (14) 1306-1316
  • 5 Herridge MS, Tansey CM, Matté A , et al; Canadian Critical Care Trials Group. Functional disability 5 years after acute respiratory distress syndrome. N Engl J Med 2011; 364 (14) 1293-1304
  • 6 Desai SV, Law TJ, Needham DM. Long-term complications of critical care. Crit Care Med 2011; 39 (2) 371-379
  • 7 Elliott D, Davidson JE, Harvey MA , et al. Exploring the scope of post-intensive care syndrome therapy and care: engagement of non-critical care providers and survivors in a second stakeholders meeting. Crit Care Med 2014; 42 (12) 2518-2526
  • 8 Hopkins RO, Suchyta MR, Farrer TJ, Needham D. Improving post-intensive care unit neuropsychiatric outcomes: understanding cognitive effects of physical activity. Am J Respir Crit Care Med 2012; 186 (12) 1220-1228
  • 9 Salisbury LG, Merriweather JL, Walsh TS. The development and feasibility of a ward-based physiotherapy and nutritional rehabilitation package for people experiencing critical illness. Clin Rehabil 2010; 24 (6) 489-500
  • 10 Needham DM, Korupolu R, Zanni JM , et al. Early physical medicine and rehabilitation for patients with acute respiratory failure: a quality improvement project. Arch Phys Med Rehabil 2010; 91 (4) 536-542
  • 11 Hodgson CL, Stiller K, Needham DM , et al. Expert consensus and recommendations on safety criteria for active mobilization of mechanically ventilated critically ill adults. Crit Care 2014; 18 (6) 658
  • 12 Peitz GJ, Balas MC, Olsen KM, Pun BT, Ely EW. Top 10 myths regarding sedation and delirium in the ICU. Crit Care Med 2013; 41 (9) (Suppl. 01) S46-S56
  • 13 Barr J, Fraser GL, Puntillo K , et al; American College of Critical Care Medicine. Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med 2013; 41 (1) 263-306
  • 14 Jackson JC, Ely EW, Morey MC , et al. Cognitive and physical rehabilitation of intensive care unit survivors: results of the RETURN randomized controlled pilot investigation. Crit Care Med 2012; 40 (4) 1088-1097
  • 15 Girard TD, Kress JP, Fuchs BD , et al. Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial. Lancet 2008; 371 (9607) 126-134
  • 16 Davydow DS, Zatzick D, Hough CL, Katon WJ. In-hospital acute stress symptoms are associated with impairment in cognition 1 year after intensive care unit admission. Ann Am Thorac Soc 2013; 10 (5) 450-457
  • 17 Simons KS, Park M, Kohlrausch A , et al. Noise pollution in the ICU: time to look into the mirror. Crit Care 2014; 18 (4) 493
  • 18 Davydow DS, Desai SV, Needham DM, Bienvenu OJ. Psychiatric morbidity in survivors of the acute respiratory distress syndrome: a systematic review. Psychosom Med 2008; 70 (4) 512-519
  • 19 Wade DM, Brewin CR, Howell DC, White E, Mythen MG, Weinman JA. Intrusive memories of hallucinations and delusions in traumatized intensive care patients: An interview study. Br J Health Psychol 2015; 20 (3) 613-631
  • 20 Wade DM, Howell DC, Weinman JA , et al. Investigating risk factors for psychological morbidity three months after intensive care: a prospective cohort study. Crit Care 2012; 16 (5) R192
  • 21 Jones C, Griffiths RD, Humphris G, Skirrow PM. Memory, delusions, and the development of acute posttraumatic stress disorder-related symptoms after intensive care. Crit Care Med 2001; 29 (3) 573-580
  • 22 Badia-Castelló M, Trujillano-Cabello J, Serviá-Goixart L, March-Llanes J, Rodríguez-Pozo A. Recall and memory after intensive care unit stay. Development of posttraumatic stress disorder [in Spanish]. Med Clin (Barc) 2006; 126 (15) 561-566
  • 23 Colville G, Kerry S, Pierce C. Children's factual and delusional memories of intensive care. Am J Respir Crit Care Med 2008; 177 (9) 976-982
  • 24 Svenningsen H. Associations between sedation, delirium and post-traumatic stress disorder and their impact on quality of life and memories following discharge from an intensive care unit. Dan Med J 2013; 60 (4) B4630
  • 25 Ringdal M, Plos K, Lundberg D, Johansson L, Bergbom I. Outcome after injury: memories, health-related quality of life, anxiety, and symptoms of depression after intensive care. J Trauma 2009; 66 (4) 1226-1233
  • 26 Kiekkas P, Theodorakopoulou G, Spyratos F, Baltopoulos GI. Psychological distress and delusional memories after critical care: a literature review. Int Nurs Rev 2010; 57 (3) 288-296
  • 27 Kalfon P, Mimoz O, Auquier P , et al. Development and validation of a questionnaire for quantitative assessment of perceived discomforts in critically ill patients. Intensive Care Med 2010; 36 (10) 1751-1758
  • 28 Rotondi AJ, Chelluri L, Sirio C , et al. Patients' recollections of stressful experiences while receiving prolonged mechanical ventilation in an intensive care unit. Crit Care Med 2002; 30 (4) 746-752
  • 29 Granja C, Lopes A, Moreira S, Dias C, Costa-Pereira A, Carneiro A. JMIP Study Group. Patients' recollections of experiences in the intensive care unit may affect their quality of life. Crit Care 2005; 9 (2) R96-R109
  • 30 Russell S. An exploratory study of patients' perceptions, memories and experiences of an intensive care unit. J Adv Nurs 1999; 29 (4) 783-791
  • 31 Wang K, Zhang B, Li C, Wang C. Qualitative analysis of patients' intensive care experience during mechanical ventilation. J Clin Nurs 2009; 18 (2) 183-190
  • 32 Green A. An exploratory study of patients' memory recall of their stay in an adult intensive therapy unit. Intensive Crit Care Nurs 1996; 12 (3) 131-137
  • 33 Fenn B. Coma alarm dreams on paediatric intensive care. Intensive Care Med 2014; 40 (10) 1568-1569
  • 34 Misak CJ. The critical care experience: a patient's view. Am J Respir Crit Care Med 2004; 170 (4) 357-359
  • 35 Scott C. The demons that can't be warded off. The Sunday Times. 2012; October 14. Available at: http://www.thesundaytimes.co.uk/sto/Magazine/Features/article1143544.ece . Assessed January 14, 2015
  • 36 Ringdal M, Johansson L, Lundberg D, Bergbom I. Delusional memories from the intensive care unit—experienced by patients with physical trauma. Intensive Crit Care Nurs 2006; 22 (6) 346-354
  • 37 Schindler AW, Schindler N, Enz F, Lueck A, Olderog T, Vagts DA. ICU personnel have inaccurate perceptions of their patients' experiences. Acta Anaesthesiol Scand 2013; 57 (8) 1032-1040
  • 38 Rozanski A, Blumenthal JA, Kaplan J. Impact of psychological factors on the pathogenesis of cardiovascular disease and implications for therapy. Circulation 1999; 99 (16) 2192-2217
  • 39 Komamura K, Fukui M, Iwasaku T, Hirotani S, Masuyama T. Takotsubo cardiomyopathy: Pathophysiology, diagnosis and treatment. World J Cardiol 2014; 6 (7) 602-609
  • 40 Henderson KM, Clark CJ, Lewis TT , et al. Psychosocial distress and stroke risk in older adults. Stroke 2013; 44 (2) 367-372
  • 41 Vlastelica M. Emotional stress as a trigger in sudden cardiac death. Psychiatr Danub 2008; 20 (3) 411-414
  • 42 Mawdsley JE, Rampton DS. Psychological stress in IBD: new insights into pathogenic and therapeutic implications. Gut 2005; 54 (10) 1481-1491
  • 43 Anton PA. Stress and mind-body impact on the course of inflammatory bowel diseases. Semin Gastrointest Dis 1999; 10 (1) 14-19
  • 44 Herrmann M, Schölmerich J, Straub RH. Stress and rheumatic diseases. Rheum Dis Clin North Am 2000; 26 (4) 737-763 , viii
  • 45 Green McDonald P, O'Connell M, Lutgendorf SK. Psychoneuroimmunology and cancer: a decade of discovery, paradigm shifts, and methodological innovations. Brain Behav Immun 2013; 30 (Suppl): S1-S9
  • 46 Deckx N, Lee WP, Berneman ZN, Cools N. Neuroendocrine immunoregulation in multiple sclerosis. Clin Dev Immunol 2013; 2013: 705232
  • 47 Vlajinac H, Sipetic S, Marinkovic J , et al. The stressful life events and Parkinson's disease: a case-control study. Stress Health 2013; 29 (1) 50-55
  • 48 Maruta T, Colligan RC, Malinchoc M, Offord KP. Optimists vs pessimists: survival rate among medical patients over a 30-year period. Mayo Clin Proc 2000; 75 (2) 140-143
  • 49 Levy BR, Slade MD, Kunkel SR, Kasl SV. Longevity increased by positive self-perceptions of aging. J Pers Soc Psychol 2002; 83 (2) 261-270
  • 50 Siegler IC, Peterson BL, Barefoot JC, Williams RB. Hostility during late adolescence predicts coronary risk factors at mid-life. Am J Epidemiol 1992; 136 (2) 146-154
  • 51 Barefoot JC, Dahlstrom WG, Williams Jr RB. Hostility, CHD incidence, and total mortality: a 25-year follow-up study of 255 physicians. Psychosom Med 1983; 45 (1) 59-63
  • 52 Yanek LR, Kral BG, Moy TF , et al. Effect of positive well-being on incidence of symptomatic coronary artery disease. Am J Cardiol 2013; 112 (8) 1120-1125
  • 53 Giltay EJ, Geleijnse JM, Zitman FG, Hoekstra T, Schouten EG. Dispositional optimism and all-cause and cardiovascular mortality in a prospective cohort of elderly Dutch men and women. Arch Gen Psychiatry 2004; 61 (11) 1126-1135
  • 54 Smith PJ, Blumenthal JA, Carney RM , et al. Neurobehavioral functioning and survival following lung transplantation. Chest 2014; 145 (3) 604-611
  • 55 Corruble E, Barry C, Varescon I, Falissard B, Castaing D, Samuel D. Depressive symptoms predict long-term mortality after liver transplantation. J Psychosom Res 2011; 71 (1) 32-37
  • 56 Dew MA, Kormos RL, Roth LH, Murali S, DiMartini A, Griffith BP. Early post-transplant medical compliance and mental health predict physical morbidity and mortality one to three years after heart transplantation. J Heart Lung Transplant 1999; 18 (6) 549-562
  • 57 Zelle DM, Dorland HF, Rosmalen JG , et al. Impact of depression on long-term outcome after renal transplantation: a prospective cohort study. Transplantation 2012; 94 (10) 1033-1040
  • 58 Pattison EM, Lapins NA, Doerr HA. Faith healing. A study of personality and function. J Nerv Ment Dis 1973; 157 (6) 397-409
  • 59 Spiegel D. Mesmer minus magic: hypnosis and modern medicine. Int J Clin Exp Hypn 2002; 50 (4) 397-406
  • 60 Bekhterev V. Hypnosis. Suggestion. Telepathy. Moscow: Thought; 1994. (Russian)
  • 61 Dispenza J. You Are the Placebo. Making Your Mind Matter. Hay House, Inc.; 2014
  • 62 Erickson MH. Hypnotic psychotherapy. Med Clin North Am 1948; 32: 571-583
  • 63 Erickson MH, Hershman S, Bryant ME. Panel discussion on hypnosis. Northwest Med 1959; 58: 1404-1414
  • 64 Erickson MH. Hypnotherapy: the patient's right to both success and failure. Am J Clin Hypn 1965; 8: 254-257
  • 65 Beecher HK. The powerful placebo. J Am Med Assoc 1955; 159 (17) 1602-1606
  • 66 Bingel U. Placebo Competence Team. Avoiding nocebo effects to optimize treatment outcome. JAMA 2014; 312 (7) 693-694
  • 67 Geers AL, Helfer SG, Kosbab K, Weiland PE, Landry SJ. Reconsidering the role of personality in placebo effects: dispositional optimism, situational expectations, and the placebo response. J Psychosom Res 2005; 58 (2) 121-127
  • 68 Loftus EF. Leading questions and the eyewitness report. Cognit Psychol 1975; 7 (4) 560-572
  • 69 Benedetti F. How the doctor's words affect the patient's brain. Eval Health Prof 2002; 25 (4) 369-386
  • 70 Gracely RH, Dubner R, Deeter WR, Wolskee PJ. Clinicians' expectations influence placebo analgesia. Lancet 1985; 1 (8419) 43
  • 71 Schelling G, Stoll C, Haller M , et al. Health-related quality of life and posttraumatic stress disorder in survivors of the acute respiratory distress syndrome. Crit Care Med 1998; 26 (4) 651-659
  • 72 Guttormson JL. “Releasing a lot of poisons from my mind”: patients' delusional memories of intensive care. Heart Lung 2014; 43 (5) 427-431
  • 73 Bartlett FC. Remembering: A Study in Experimental and Social Psychology. Cambridge University Press; 1932
  • 74 Loftus EF. The malleability of human memory. Am Sci 1979; 67 (3) 312-320
  • 75 Loftus EF. Lost in the mall: misrepresentations and misunderstandings. Ethics Behav 1999; 9 (1) 51-60
  • 76 Loftus E. Dispatch from the (un)civil memory wars. Lancet 2004; 364 (Suppl. 01) s20-s21
  • 77 Morgan III CA, Southwick S, Steffian G, Hazlett GA, Loftus EF. Misinformation can influence memory for recently experienced, highly stressful events. Int J Law Psychiatry 2013; 36 (1) 11-17
  • 78 Laney C, Loftus EF. Traumatic memories are not necessarily accurate memories. Can J Psychiatry 2005; 50 (13) 823-828
  • 79 Laney C, Loftus EF. Emotional content of true and false memories. Memory 2008; 16 (5) 500-516
  • 80 Frenda SJ, Patihis L, Loftus EF, Lewis HC, Fenn KM. Sleep deprivation and false memories. Psychol Sci 2014; 25 (9) 1674-1681
  • 81 Knowles RE, Tarrier N. Evaluation of the effect of prospective patient diaries on emotional well-being in intensive care unit survivors: a randomized controlled trial. Crit Care Med 2009; 37 (01) 184-191
  • 82 Jones C, Bäckman C, Capuzzo M , et al; RACHEL group. Intensive care diaries reduce new onset post traumatic stress disorder following critical illness: a randomised, controlled trial. Crit Care 2010; 14 (5) R168
  • 83 Garrouste-Orgeas M, Coquet I, Périer A , et al. Impact of an intensive care unit diary on psychological distress in patients and relatives. Crit Care Med 2012; 40 (7) 2033-2040
  • 84 Mehlhorn J, Freytag A, Schmidt K , et al. Rehabilitation interventions for postintensive care syndrome: a systematic review. Crit Care Med 2014; 42 (5) 1263-1271
  • 85 Peris A, Bonizzoli M, Iozzelli D , et al. Early intra-intensive care unit psychological intervention promotes recovery from post traumatic stress disorders, anxiety and depression symptoms in critically ill patients. Crit Care 2011; 15 (1) R41
  • 86 Schiller D, Monfils MH, Raio CM, Johnson DC, Ledoux JE, Phelps EA. Preventing the return of fear in humans using reconsolidation update mechanisms. Nature 2010; 463 (7277) 49-53
  • 87 Tembo AC, Parker V, Higgins I. The experience of sleep deprivation in intensive care patients: findings from a larger hermeneutic phenomenological study. Intensive Crit Care Nurs 2013; 29 (6) 310-316
  • 88 Jones C, Griffiths RD, Humphris G. Disturbed memory and amnesia related to intensive care. Memory 2000; 8 (2) 79-94
  • 89 Thompson DF, Pierce DR. Drug-induced nightmares. Ann Pharmacother 1999; 33 (1) 93-98
  • 90 Caiuby AV, Andreoli PB, Andreoli SB. Post-traumatic stress disorder in intensive care unit patients. [in Portuguese]. Rev Bras Ter Intensiva 2010; 22 (1) 77-84
  • 91 Wade D, Hardy R, Howell D, Mythen M. Identifying clinical and acute psychological risk factors for PTSD after critical care: a systematic review. Minerva Anestesiol 2013; 79 (8) 944-963
  • 92 Treggiari MM, Romand JA, Yanez ND , et al. Randomized trial of light versus deep sedation on mental health after critical illness. Crit Care Med 2009; 37 (9) 2527-2534
  • 93 Strøm T, Stylsvig M, Toft P. Long-term psychological effects of a no-sedation protocol in critically ill patients. Crit Care 2011; 15 (6) R293
  • 94 Strøm T, Martinussen T, Toft P. A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial. Lancet 2010; 375 (9713) 475-480
  • 95 Harvey AG, Brewin CR, Jones C, Kopelman MD. Coexistence of posttraumatic stress disorder and traumatic brain injury: towards a resolution of the paradox. J Int Neuropsychol Soc 2003; 9 (4) 663-676
  • 96 Sheen L, Oates J. A phenomenological study of medically induced unconsciousness in intensive care. Aust Crit Care 2005; 18 (1) 25-29 , 31–32
  • 97 Huprich SK. Reclaiming the value of assessing unconscious and subjective psychological experience. J Pers Assess 2011; 93 (2) 151-160
  • 98 Rämä P, Relander-Syrjänen K, Ohman J, Laakso A, Näätänen R, Kujala T. Semantic processing in comatose patients with intact temporal lobes as reflected by the N400 event-related potential. Neurosci Lett 2010; 474 (2) 88-92
  • 99 Pape TL, Rosenow JM, Steiner M , et al. Placebo-controlled trial of familiar auditory sensory training for acute severe traumatic brain injury: a preliminary report. Neurorehabil Neural Repair 2015; 29 (6) 537-547
  • 100 Szilagyi AK. Suggestive communication at the intensive care unit. In: Varga K, , ed. Beyond the Words. Communication and Suggestion in Medical Practice. Nova Science Publishers: New York; 2011: 223-237
  • 101 Papathanassoglou ED, Patiraki EI. Transformations of self: a phenomenological investigation into the lived experience of survivors of critical illness. Nurs Crit Care 2003; 8 (1) 13-21
  • 102 Diószeghy C, Varga K, Fejes K, Pénzes I. Use of positive suggestions in medical practice: experiences in the intensive care unit. [in Hungarian]. Orv Hetil 2000; 141 (19) 1009-1013
  • 103 Varga K. (2011): Possibilities of suggestive communication. In: Varga K, ed., Beyond the Words. Communication and Suggestion in Medical Practice. New York: Nova Science Publishers; 3-16
  • 104 Varga K. Suggestive techniques connected to medical interventions. Interv Med Appl Sci 2013; 5 (3) 95-100
  • 105 Varga K, Varga Z, Fritúz G. Psychological support based on positive suggestions in the treatment of a critically ill ICU patient - a case report. Interv Med Appl Sci 2013; 5 (4) 153-161
  • 106 Szilágyi AK., Diószeghy C, Fritúz G, Gál J, Varga K. Shortening the length of stay and mechanical ventilation time by using positive suggestions via MP3 players for ventilated patients. Interv Med Appl Sci 2014; 6 (1) 3-15
  • 107 Varga K, Diószeghy C, Fritúz D. Suggestive communication with the ventilated patient. Eur J Ment Health 2007; 2: 137-147
  • 108 Szilágyi AK, Diószeghy CS, Benczúr L, Varga K. Effectiveness of psychological support based on positive suggestion with the ventilated patient. Eur J Ment Health 2007; 2: 149-170
  • 109 Schlanger J, Fritúz G, Varga K. Therapeutic suggestion helps to cut back on drug intake for mechanically ventilated patients in intensive care unit. Interv Med Appl Sci 2013; 5 (4) 145-152
  • 110 Gajic O. The hand. Am J Respir Crit Care Med 2011; 183 (12) 1587
  • 111 Colombo R, Corona A, Praga F , et al. A reorientation strategy for reducing delirium in the critically ill. Results of an interventional study. Minerva Anestesiol 2012; 78 (9) 1026-1033
  • 112 Turon M, Fernandez-Gonzalo S, Gomez-Simon V, Blanch L, Jodar M. Cognitive stimulation in ICU patients: should we pay more attention?. Crit Care 2013; 17 (3) 158