Abstract
Background The cardioplegia is one of the most significant tools used to increase myocardial
protection. The aim of our study is to compare the use of Custodiol solution versus
intermitted blood cardioplegia in a retrospective analysis of data for patients who
underwent arterial switch operation in our institution.
Material and Methods From January 2008 to March 2011, myocardial protection was performed in 44 neonates
(blood group) with intermittent blood cardioplegia. From March 2011 to November 2014,
myocardial protection was performed in 50 neonates (Custodiol group) with one-shot
anterograde Custodiol cardioplegia.
Results Cardiopulmonary bypass and aortic cross-clamp were more favorable in Custodiol group
(p-value 0.005 and ≤ 0.00001). The rate of delayed sternal closure was 63.6% in the
blood group and 52% in the Custodiol group (p = 0.25). In the postoperative outcomes we did not find differences between the two
groups. The 30-day mortality was one patient in the blood group (p = 0.46). We observed a transient ischemic electrocardiogram in 10 patients of the
blood group and in 14 of the Custodiol group (p = 0.72), all cases with full resolution during hospitalization without coronary reoperation.
A trend of higher peak of troponin-I and brain natriuretic peptide in Custodiol group
has been reported.
Conclusion No prefect cardioplegia exists, the Custodiol solution does not cause extra/additional
myocardial damage in arterial switch operation. In our experience this strategy seems
warranted to simplify the procedure and to be more comfortable for the surgeon.
Keywords
cardiopulmonary bypass - congenital heart disease - perfusion - pediatric
