Virus inhibitory activity of methanol extracts of Halimodendron halodendron Voss.

This paper explores the effect of methanol extract of Halimodendron halodendron Voss. leaf against bird flu virus (strain A/FPV/Rostock/34 (H7N1)). Plant material (dry leaves of H. halodendron) was extracted with methyl alcohol after chloroform treatment. The methanol extract contains 8 – 10% of chlorophyll, 10 – 11% of flavonol glycosides with the rutin structure as it was shown by High-Performance Liquid Chromatography and triterpenoid glycosides as the main part of the extract. When studying the virus inhibiting properties of H. halodendron extract it is established that in doses from 0,5 to 4 mg on 1 kg of weight of a chicken embryo the preparation didn't possess ability to suppress a flu virus reproduction. The increase in a dose of a preparation to 5 mg/kg led to suppression of a reproduction of a virus for 20%. The further increase in a dose of a preparation to 50 mg/kg of weight of an animal leads to full suppression of a reproduction of a virus. The current findings have clearly demonstrated that H. halodendron leaf extract has anti-H7N1 avian influenza properties [1].

References:

[1] Gubareva LV, Molecular mechanisms of influenza virus resistance to neuraminidase inhibitors. Virus Res 2004; 103: 199 – 203