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Synfacts 2016; 12(07): 0662
DOI: 10.1055/s-0035-1562248
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of AMG 337

Contributor(s):
Philip Kocienski
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Publication History

Publication Date:
17 June 2016 (online)

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Key words

AMG 337 - MET kinase inhibitor - 1,6-naphthyridine-5(6H)-one ring formation - [1,2,4]triazolo[4,3-a]pyridine ring formation - copper catalysis - O-arylation - cyclodehydration