Synthesis 2016; 48(12): 1769-1781
DOI: 10.1055/s-0035-1561622
short review
© Georg Thieme Verlag Stuttgart · New York

Asymmetric Hydrogenation of Heteroarenes with Multiple Heteroatoms

Zhang-Pei Chen
State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P. R. of China   Email: [email protected]
,
Yong-Gui Zhou*
State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P. R. of China   Email: [email protected]
› Author Affiliations
Further Information

Publication History

Received: 30 January 2016

Accepted after revision: 18 March 2016

Publication Date:
20 April 2016 (online)


Abstract

Enantiopure heterocyclic architectures containing two or more heteroatoms in the ring system have attracted considerable attraction due to this motif playing a role of great importance in asymmetric synthesis and the pharmaceutical chemistry. This review focused on recent advances in the homogeneous asymmetric hydrogenation of heteroarenes with multiple heteroatoms, which provide an efficient and practical method to structural diverse chiral heterocyclic compounds.

1 Introduction

2 Asymmetric Hydrogenation of Five-Membered-Ring Hetero­arenes

2.1 Imidazoles and Oxazoles

2.2 Pyrazole Derivatives

2.3 Benzisoxazoles

3 Asymmetric Hydrogenation of Six-Membered-Ring Heteroarenes

3.1 Quinoxalines

3.2 Quinazolines

3.3 Pyrimidines

3.4 Pyrazines

4 Asymmetric Hydrogenation of Fused Nitrogen Heteroarenes

4.1 Heteroarenes Containing a Ring-Junction Nitrogen

4.2 Heteroarenes Containing a Fused Pyridine Ring

5 Conclusions and Outlook

 
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