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Pharmacopsychiatry 2015; 48(07): 268-273
DOI: 10.1055/s-0035-1559667
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Effect of Adjunctive Celecoxib on BDNF in Manic Patients Undergoing Electroconvulsive Therapy: a Randomized Double Blind Controlled Trial

M. Kargar
1   Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of
,
A. Yoosefi
2   Amiralam Hospital, Department of Anesthesiology, Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of
,
S. Akhondzadeh
3   Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences,Tehran, Iran, Islamic Republic of
,
V. Artonian
4   Department of Psychiatry, Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of
,
A. Ashouri
5   School of public health, Department of epidemiology and biostatistics, Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of
,
P. Ghaeli
6   Faculty of Pharmacy & Psychiatry and Psychology Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of
› Author Affiliations
Further Information

Publication History

received 05 July 2015
revised 05 July 2015

accepted 27 July 2015

Publication Date:
23 September 2015 (online)

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Abstract

Introduction: The possible effect of inflammatory factors on decreasing BDNF has been proposed in the literature. There is conflicting evidence regarding association between BDNF level alteration and treatment response in depressive patients undergoing electroconvulsive therapy (ECT). This study investigated the effects of celecoxib in manic patients undergoing ECT on treatment response and BDNF levels.

Methods: This randomized, double-blind, clinical trial included 35 manic patients who received either celecoxib (200 mg twice daily) or placebo, from one day before the 1st ECT session throughout the 6th session. BDNF levels were measured at baseline, 1st, 3rd and 6th ECT sessions. Young mania rating scale was used to assess treatment response.

Results: Adding celecoxib was not associated with a significant rise in BDNF levels following ECT. No difference was noted between groups in terms of treatment response. No significant association was found between changes in BDNF levels and patients’ responses.

Discussion: Adjuvant celecoxib did not significantly affect the BDNF level or the treatment response following ECT in manic patients.

Key words

bipolar disorder - electroconvulsive therapy (ECT) - bipolar disorder treatment
 

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