Planta Medica Letters 2015; 2(01): e31-e34
DOI: 10.1055/s-0035-1557794
Letter
Georg Thieme Verlag KG Stuttgart · New York

Two Novel Guaiane Sesquiterpenes from the Whole Plant of Youngia japonica

Ji Young Lee
1  Research Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology, Daejeon, Korea
2  Graduate School of New Drug Discovery and Development, Chungnam National University, Daejeon, Korea
,
Mi-Ran Cha
1  Research Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology, Daejeon, Korea
,
Mi Ri Kim
1  Research Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology, Daejeon, Korea
,
Kwangho Lee
1  Research Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology, Daejeon, Korea
,
Sang-Un Choi
1  Research Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology, Daejeon, Korea
,
Shi Yong Ryu
1  Research Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology, Daejeon, Korea
2  Graduate School of New Drug Discovery and Development, Chungnam National University, Daejeon, Korea
› Author Affiliations
Further Information

Publication History

received 13 April 2015
revised 30 June 2015

accepted 30 June 2015

Publication Date:
06 August 2015 (online)

Abstract

Two new guaiane-type sesquiterpenes (1 and 2) together with eight related sesquiterpenoidal constituents (310) were isolated from the whole extract of Youngia japonica. The chemical structures of 110 were established by spectroscopic analyses as 4-epi-isolipidiol (1), 4′-p-hydroxyphenylacetyl crepiside E (2), isolipidiol (3), isoambeboin (4), grosheimin (5), annuionone D (6), loliolide (7), youngiajaponicoside A (8), crepiside H (9), and crepiside E (10), respectively. Among the isolated components, 5 exhibited a significant inhibitory effect on the proliferation of cultured human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15).

Supporting Information