TY - JOUR AU - Lee, Ji Young; Cha, Mi-Ran; Kim, Mi Ri; Lee, Kwangho; Choi, Sang-Un; Ryu, Shi Yong TI - Two Novel Guaiane Sesquiterpenes from the Whole Plant of Youngia japonica SN - 2199-157X PY - 2015 JF - Planta Medica Letters LA - EN VL - 2 IS - 01 SP - e31 EP - e34 DA - 2015/08/06 KW - Youngia japonica KW - Asteraceae KW - guaiane sesquiterpene KW - cytotoxicity AB - Two new guaiane-type sesquiterpenes (1 and 2) together with eight related sesquiterpenoidal constituents (3–10) were isolated from the whole extract of Youngia japonica. The chemical structures of 1–10 were established by spectroscopic analyses as 4-epi-isolipidiol (1), 4′-p-hydroxyphenylacetyl crepiside E (2), isolipidiol (3), isoambeboin (4), grosheimin (5), annuionone D (6), loliolide (7), youngiajaponicoside A (8), crepiside H (9), and crepiside E (10), respectively. Among the isolated components, 5 exhibited a significant inhibitory effect on the proliferation of cultured human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15). PB - Georg Thieme Verlag KG DO - 10.1055/s-0035-1557794 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0035-1557794 ER -