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Planta Med 2015; 81(08): 637-647
DOI: 10.1055/s-0035-1545946
Reviews
Georg Thieme Verlag KG Stuttgart · New York

Plants and Their Bioactive Compounds with the Potential to Enhance Mechanisms of Inherited Cardiac Regeneration

Zhen Zhou
1   Laboratory of Innovative Medicine, Hong Kong
,
Dianbin Li
2   Emergency Department, Tianshan Chinese Medicine Hospital, Shanghai, China
,
Hua Zhou
3   Department of Cardiology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
,
Xiaoli Lin
1   Laboratory of Innovative Medicine, Hong Kong
,
Censing Li
4   Queen Mary University of London, London, UK
,
Mingfeng Tang
1   Laboratory of Innovative Medicine, Hong Kong
,
Zhou Feng
3   Department of Cardiology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
,
Ming Li
1   Laboratory of Innovative Medicine, Hong Kong
› Author Affiliations
Further Information

Publication History

received 28 July 2014
revised 20 March 2015

accepted 23 March 2015

Publication Date:
27 May 2015 (online)

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Abstract

This article reviews the current progress and research indications in the application of natural plant compounds with the potential for the treatment of cardiovascular diseases. Our understanding of how to apply natural plant compounds to enhance mechanisms of inherited cardiac regeneration, which is physiologically pertinent to myocyte turnover or minor cardiac repair, for substantial cardiac regeneration to repair pathological heart injuries is discussed. Although significant progress has been made in the application of natural plant compounds for therapy of heart diseases, the understanding or the application of these compounds specifically for enhancing mechanisms of inherited cardiac regeneration for the treatment of cardiovascular diseases is little. Recent recognition of some natural plant compounds that can repair damaged myocardial tissues through enhancing mechanisms of inherited cardiac regeneration has offered an alternative for clinical translation. Application of natural plant compounds, which show the activity of manipulating gene expressions in such a way to enhance mechanisms of inherited cardiac regeneration for cardiac repair, may provide a promising strategy for the reconstruction of damaged cardiac tissues due to cardiovascular diseases.

Key words

natural plant compounds - cardiovascular diseases - myocardial regeneration - mechanisms of inherited cardiac regeneration - cardiovascular diseases - cardiogenin
 

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