Planta Med 2015; 81(03): 241-246
DOI: 10.1055/s-0034-1396151
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Icetexane Diterpenoids from Perovskia atriplicifolia

Zhi-Yong Jiang
1  School of Chemistry and Biotechnology, Yunnan Minzu University, Kunming, Yunnan, China
,
Yi-Jiang Yu
1  School of Chemistry and Biotechnology, Yunnan Minzu University, Kunming, Yunnan, China
,
Chao-Guan Huang
1  School of Chemistry and Biotechnology, Yunnan Minzu University, Kunming, Yunnan, China
,
Xiang-Zhong Huang
1  School of Chemistry and Biotechnology, Yunnan Minzu University, Kunming, Yunnan, China
2  Key Laboratory of Yi Medicine Resources & Pharmacodynamics Research, Yunnan Minzu University, Kunming, Yunnan, China
,
Qiu-Fen Hu
1  School of Chemistry and Biotechnology, Yunnan Minzu University, Kunming, Yunnan, China
,
Guang-Yu Yang
3  Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming, Yunnan, China
,
Hong-Bin Wang
1  School of Chemistry and Biotechnology, Yunnan Minzu University, Kunming, Yunnan, China
,
Xiang-Yu Zhang
1  School of Chemistry and Biotechnology, Yunnan Minzu University, Kunming, Yunnan, China
,
Gan-Peng Li
1  School of Chemistry and Biotechnology, Yunnan Minzu University, Kunming, Yunnan, China
› Author Affiliations
Further Information

Publication History

received 17 August 2014
revised 26 November 2014

accepted 28 November 2014

Publication Date:
22 January 2015 (online)

Abstract

Five new icetexane diterpenoids, namely, perovskatones B–D (1, 3, 4), 1α-hydroxybrussonol (2), and 1α-hydroxypisiferanol (5), were isolated from Perovskia atriplicifolia, together with a new natural product (6) and two known compounds, przewalskin E (7) and brussonol (8). The structures of the new compounds were elucidated by detailed analyses of their MS, IR, 1D, and 2D NMR data. Compounds 18 were assayed for their inhibitory hepatitis B virus activities in the HepG 2.2.15 cell line. The results suggested that compounds 1 and 2 possessed noticeable anti-hepatitis B virus activity in vitro, suppressing the replication of hepatitis B virus DNA with selectivity index values of 154.3 and 137.7, respectively.

Supporting Information