Pharmacopsychiatry 2015; 48(02): 78-79
DOI: 10.1055/s-0034-1394399
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Single Ketamine Infusion and Neurocognitive Performance in Bipolar Depression

A. Permoda-Osip
1  Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
,
J. Kisielewski
1  Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
,
A. Bartkowska-Sniatkowska
2  Department of Pediatric Anaesthesiology and Intensive Therapy, Poznan University of Medical Sciences, Poznan, Poland
,
J. K. Rybakowski
1  Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
› Author Affiliations
Further Information

Publication History

Publication Date:
27 October 2014 (eFirst)

Abstract

We estimated neurocognitive performance using the trail making test (TMT) and the Stroop color-word interference test before, and on the 3rd day after a single infusion of ketamine, in 18 bipolar depressed patients receiving mood-stabilizing drugs. The performance on all tests significantly improved on the 3rd day after ketamine infusion which correlated positively with baseline intensity of neuropsychological impairment and was not associated either with baseline intensity of depression or reduction of depressive symptoms after 3 or 7 days. The results suggest that in such population of patients, single ketamine infusion may improve neuropsychological performance independently of antidepressant effect.