Einfluss oraler Einnahme von Kollagen-Peptiden auf relevante Parameter der Hautalterung: Hautfeuchtigkeit, Hautelastizität und Hautrauigkeit

Zusammenfassung

Mit zunehmendem Alter und unter Einfluss weiterer Noxen, wie UV-Exposition und Nikotinabusus, kommt es zu einer Abnahme der dermalen extrazellulären Matrix und des Kollagengerüsts. Dies führt zu einer Abnahme der Hautdicke, Elastizität und Feuchtigkeit und damit einhergehend zu einer verstärkten Faltenbildung. Studien haben gezeigt, dass die orale Aufnahme von speziellen Kollagen-Peptiden über einen längeren Zeitraum die Hautphysiologie positiv beeinflusst. In der vorliegenden klinisch-dermatologischen Prüfung zeigte die Einnahme von kurzkettigen Kollagen-Peptiden (Prüfpräparat: ELASTEN^®) über einen Zeitraum von 3 Monaten signifikant positive und nachhaltige Effekte auf die Hautparameter Elastizität, Feuchtigkeit und Hautrauigkeit.

Abstract

With increasing age, the dermal matrix and collagen content decreases which results in a loss of skin hydration, elasticity and increased wrinkling. In addition to the normal ageing process, several other factors like UV radiation or smoking negatively influence skin physiology. Prior studies demonstrated that the oral intake of bioactive collagen peptides induces beneficial effects on human skin structure and functioning. In this study the oral intake of special collagen peptides (investigational product: ELASTEN^®) for 3 months results in significant and sustainable improvements in skin parameters including skin hydration, elasticity and roughness.

• Literatur

• 1 Smalls LK, Wickett R, Visscher MO. Effect of dermal thickness, tissue composition, and body site on skin biomechanical properties. Skin research and technology: official journal of International Society for Bioengineering and the Skin 2006; 12: 43-49
• 2 Calleja-Agius J, Muscat-Baron Y, Brincat MP. Skin ageing. Menopause international 2007; 13: 60-64
• 3 Proksch E, Schunck M, Zague V et al. Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis. Skin pharmacology and physiology 2014; 27: 113-119
• 4 Proksch E, Segger D, Degwert J et al. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. Skin pharmacology and physiology 2014; 27: 47-55
• 5 Tanaka M, Koyama Y, Nomura Y. Effects of collagen peptide ingestion on UV-B-induced skin damage. Bioscience, biotechnology, and biochemistry 2009; 73: 930-932
• 6 Oba C, Ohara H, Morifuji M et al. Collagen hydrolysate intake improves the loss of epidermal barrier function and skin elasticity induced by UVB irradiation in hairless mice. Photodermatology, photoimmunology & photomedicine 2013; 29: 204-211
• 7 Ohara H, Matsumoto H, Ito K et al. Comparison of quantity and structures of hydroxyproline-containing peptides in human blood after oral ingestion of gelatin hydrolysates from different sources. Journal of agricultural and food chemistry 2007; 55: 1532-1535
• 8 Iwai K, Hasegawa T, Taguchi Y et al. Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates. Journal of agricultural and food chemistry 2005; 53: 6531-6536
• 9 Oesser S, Adam M, Babel W et al. Oral administration of (14)C labeled gelatin hydrolysate leads to an accumulation of radioactivity in cartilage of mice (C57/BL). The Journal of nutrition 1999; 129: 1891-1895
• 10 Bauza E, Oberto G, Berghi A et al. Collagen-like peptide exhibits a remarkable antiwrinkle effect on the skin when topically applied: in vivo study. International journal of tissue reactions 2004; 26: 105-111
• 11 Perrin A, Bauza E, Dal Farra C et al. Stimulating effect of collagen-like peptide on the extracellular matrix of human skin: histological studies. International journal of tissue reactions 2004; 26: 97-104
• 12 Chai HJ, Li JH, Huang HN et al. Effects of sizes and conformations of fish-scale collagen peptides on facial skin qualities and transdermal penetration efficiency. Journal of biomedicine & biotechnology 2010; 2010: 757301
• 13 Zague V. A new view concerning the effects of collagen hydrolysate intake on skin properties. Archives of dermatological research 2008; 300: 479-483
• 14 Shimizu J, Asami N, Kataoka A et al. Oral collagen-derived dipeptides, prolyl-hydroxyproline and hydroxyprolyl-glycine, ameliorate skin barrier dysfunction and alter gene expression profiles in the skin. Biochemical and biophysical research communications 2015; 456: 626-630
• 15 Shigemura Y, Iwai K, Morimatsu F et al. Effect of Prolyl-hydroxyproline (Pro-Hyp), a food-derived collagen peptide in human blood, on growth of fibroblasts from mouse skin. Journal of agricultural and food chemistry 2009; 57: 444-449
• 16 Ohara H, Ichikawa S, Matsumoto H et al. Collagen-derived dipeptide, proline-hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts. The Journal of dermatology 2010; 37: 330-338