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Planta Med 2014; 80 - PPL10
DOI: 10.1055/s-0034-1382646
DOI: 10.1055/s-0034-1382646
High resolution GC/MS methods for the quantitative analysis of ginkgolic acids in Ginkgo biloba plants, extracts and dietary supplements
A GC/MS SIM method focusing on the characterization and analysis of ginkgolic acids in plant material, extracts and commercial products was developed and validated. The method involved extraction with methanol and formic acid, liquid-liquid extraction with hexane and derivatization with trimethylsulfonium hydroxide. The methylated esters were resolved with a very polar (88% cyanopropyl)aryl-polysiloxane (HP-88) GC column. Separation of positional double bond isomers for the polyunsaturated ginkgolic acid was also acheieved. Furthermore, the validated method was used to analyze Ginkgo biloba L. plant samples and dietary supplements purported to contain G. biloba extracts.