Am J Perinatol 2015; 32(02): 155-162
DOI: 10.1055/s-0034-1376393
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Severe Bronchopulmonary Dysplasia is Associated with Higher Fluid Intake in Very Low-Birth-Weight Infants: A Retrospective Study

Mindy Ming-Huey Guo
1  Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taiwan
,
Ching-Hung Chung
2  Department of Dental Laboratory Technology, Min-Hwei College of Health Care Management, Taiwan
,
Feng-Shun Chen
1  Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taiwan
,
Chih-Cheng Chen
1  Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taiwan
,
Hsin-Chun Huang
1  Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taiwan
,
Mei-Yung Chung
1  Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taiwan
3  Department of Respiratory care, Chang Gung University of Science and Technology, Chiayi Campus, Taiwan
› Author Affiliations
Further Information

Publication History

24 September 2013

14 April 2014

Publication Date:
10 June 2014 (online)

Abstract

Objective This study aims to investigate the association between fluid intake in the first 4 days of life and the subsequent severity of bronchopulmonary dysplasia (BPD) in very low-birth-weight infants (VLBWI).

Study Design A retrospective chart review of 75 infants with a gestational age of less than 32 weeks and a birth weight of < 1,500 g was performed. Demographic, clinical data, associated maternal risk factors, and amount of fluid received in the first 4 days of life were analyzed.

Results Severe BPD was associated with a lower gestational age (27.04 ± 2.073 wks vs. 28.70 ± 1.706 wks, p=0.001), lower birth weight (981.44 ± 244.54 vs. 1,199.63 ± 165.39 g, p < 0.001), use of surfactant (91.7 vs. 63%, p=0.002), patent ductus arteriousus (PDA) (70.8 vs. 37%, p=0.004), pulmonary hemorrhage (14.6 vs. 0%, p=0.045), and more fluids received from the 2nd to 4th days of life (346.44 ± 42.38 mL/kg vs. 323.91 ± 27.62 mL/kg, p=0.007). A cut off point of 345 mL/kg of fluids from the 2nd to 4th days of life was selected using receiver operating characteristic curve analysis, and remained a significant risk factor even after multiple logistic regression analysis.

Conclusion Our findings demonstrate that VLBWI who received higher fluid intake from the 2nd to 4th days of life are at an increased risk of developing severe BPD.