Planta Med 2013; 79(18): 1767-1774
DOI: 10.1055/s-0033-1351045
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Chemical Constituents from Trichilia connaroides and Their Nitric Oxide Production and α-Glucosidase Inhibitory Activities

Hong-Ying Wang
State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, P. R. China
,
Jun-Song Wang
State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, P. R. China
,
Si-Ming Shan
State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, P. R. China
,
Xiao-Bing Wang
State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, P. R. China
,
Jun Luo
State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, P. R. China
,
Ming-Hua Yang
State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, P. R. China
,
Ling-Yi Kong
State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, P. R. China
› Author Affiliations
Further Information

Publication History

received 10 April 2013
revised 05 August 2013

accepted 13 October 2013

Publication Date:
19 December 2013 (online)

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Abstract

Phytochemical investigation of the stem and bark of Trichilia connaroides led to the isolation of eight new nortriterpenoids (18), along with fifteen known compounds (923). Their structures were established based on extensive spectroscopic analysis. The absolute configuration of 2 was confirmed by X-ray crystallographic study. The nitric oxide production and α-glucosidase inhibitory effects for these isolates were evaluated: moderate to strong nitric oxide production inhibitory activities were found for 5, 6, and 1115, with IC50 values ranging from 7.5 to 26.3 µM; marked α-glucosidase inhibitory effects were observed for 22 and 23, with IC50 values of 2.3 and 0.4 µM, respectively.

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