Chemical Constituents from Trichilia connaroides and Their
                    Nitric Oxide Production and α-Glucosidase Inhibitory
                    Activities

Hong-Ying Wang; Jun-Song Wang; Si-Ming Shan; Xiao-Bing Wang; Jun Luo; Ming-Hua Yang; Ling-Yi Kong

doi:10.1055/s-0033-1351045

Planta Medica, Inhaltsverzeichnis

Planta Med 2013; 79(18): 1767-1774
DOI: 10.1055/s-0033-1351045

Natural Product Chemistry

Original Papers

Georg Thieme Verlag KG Stuttgart · New York

Chemical Constituents from Trichilia connaroides and Their Nitric Oxide Production and α-Glucosidase Inhibitory Activities

Hong-Ying Wang

State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, P. R. China

,

Jun-Song Wang

State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, P. R. China

,

Si-Ming Shan

State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, P. R. China

,

Xiao-Bing Wang

State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, P. R. China

,

Jun Luo

State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, P. R. China

,

Ming-Hua Yang

State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, P. R. China

,

Ling-Yi Kong

State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, P. R. China

› Institutsangaben

Abstract

Phytochemical investigation of the stem and bark of Trichilia connaroides led to the isolation of eight new nortriterpenoids (1–8), along with fifteen known compounds (9–23). Their structures were established based on extensive spectroscopic analysis. The absolute configuration of 2 was confirmed by X-ray crystallographic study. The nitric oxide production and α-glucosidase inhibitory effects for these isolates were evaluated: moderate to strong nitric oxide production inhibitory activities were found for 5, 6, and 11–15, with IC₅₀ values ranging from 7.5 to 26.3 µM; marked α-glucosidase inhibitory effects were observed for 22 and 23, with IC₅₀ values of 2.3 and 0.4 µM, respectively.

Key words

Trichilia connaroides - Meliaceae - nortriterpenoids - pregnanes - lignans - NO production inhibition - α-glucosidase inhibition

Volltext

Referenzen

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