Planta Med 2013; 79 - PL30
DOI: 10.1055/s-0033-1348671

Polyketide Glycosides from Bionectria ochrolenca Inhibit Biofilm Formation by Candida albicans

B Wang 1, J You 1, JB King 1, E Park 1, RH Cichewicz 1
  • 1Natural Product Discovery Group, Department of Chemistry & Biochemistry, University of Oklahoma, Norman, OK 73019

One challenge to deal with Candida albicans and other fungal infections frequently observed in immunocompromised individuals is that the microorganisms are able to self-produce biofilms resulting in the resistance to antibiotics. Fungal biofilm inhibitors could be potential therapeutic agents to treat fungal infections. In our investigation of antibiofilm agents from Bionectria ochrolenca co-culturing with a Penicillium sp., three new (1 – 3) together with four known polyketide glycosides TMC 151C-F were isolated. These molecules were found to inhibit the biofilm formation by C. albicans. Their structural elucidation and antibiofilm activity will be presented.