Polyketide Glycosides from Bionectria ochrolenca Inhibit Biofilm Formation by Candida albicans

One challenge to deal with Candida albicans and other fungal infections frequently observed in immunocompromised individuals is that the microorganisms are able to self-produce biofilms resulting in the resistance to antibiotics. Fungal biofilm inhibitors could be potential therapeutic agents to treat fungal infections. In our investigation of antibiofilm agents from Bionectria ochrolenca co-culturing with a Penicillium sp., three new (1 – 3) together with four known polyketide glycosides TMC 151C-F were isolated. These molecules were found to inhibit the biofilm formation by C. albicans. Their structural elucidation and antibiofilm activity will be presented.