Amer J Perinatol 2014; 31(03): 223-230
DOI: 10.1055/s-0033-1345264
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Postnatal Weight Gain in Preterm Infants with Severe Bronchopulmonary Dysplasia

Girija Natarajan
1  Department of Pediatrics, Wayne State University, Children's Hospital of Michigan, Detroit, Michigan
,
Yvette R. Johnson
2  Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas
,
Beverly Brozanski
3  Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania
,
Kathryn N. Farrow
4  Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
,
Isabella Zaniletti
5  Childrens' Hospital Association, Overland Park, Kansas
,
Michael A. Padula
6  Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
,
Jeanette M. Asselin
7  Children's Hospital Oakland and Research Center, Oakland, California
,
David J. Durand
7  Children's Hospital Oakland and Research Center, Oakland, California
,
Billie L. Short
8  Department of Pediatrics, George Washington University School of Medicine, Washington, District of Columbia
,
Eugenia K. Pallotto
9  Department of Pediatrics, University of Missouri School of Medicine, Kansas City, Missouri
,
Francine D. Dykes
10  Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia
,
Kristina M. Reber
11  Department of Pediatrics and Center for Perinatal Research, Division of Neonatology; Columbus, Ohio
,
Jacquelyn R. Evans
6  Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
,
Karna Murthy
4  Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
,
for the Children's Hospital Neonatal Consortium Executive Board and Study Group› Author Affiliations
Further Information

Publication History

04 March 2013

19 March 2013

Publication Date:
20 May 2013 (eFirst)

Abstract

Objectives To characterize postnatal growth failure (PGF), defined as weight < 10th percentile for postmenstrual age (PMA) in preterm (≤ 27 weeks' gestation) infants with severe bronchopulmonary dysplasia (sBPD) at specified time points during hospitalization, and to compare these in subgroups of infants who died/underwent tracheostomy and others.

Study Design Retrospective review of data from the multicenter Children's Hospital Neonatal Database (CHND).

Results Our cohort (n = 375) had a mean ± standard deviation gestation of 25 ± 1.2 weeks and birth weight of 744 ± 196 g. At birth, 20% of infants were small for gestational age (SGA); age at referral to the CHND neonatal intensive care unit (NICU) was 46 ± 50 days. PGF rates at admission and at 36, 40, 44, and 48 weeks' PMA were 33, 53, 67, 66, and 79% of infants, respectively. Tube feedings were administered to > 70% and parenteral nutrition to a third of infants between 36 and 44 weeks' PMA. At discharge, 34% of infants required tube feedings and 50% had PGF. A significantly greater (38 versus 17%) proportion of infants who died/underwent tracheostomy (n = 69) were SGA, compared with those who did not (n = 306; p < 0.01).

Conclusions Infants with sBPD commonly had progressive PGF during their NICU hospitalization. Fetal growth restriction may be a marker of adverse outcomes in this population.