A new attachment hood (Nanoshooter) for transnasal endoscopic submucosal dissection of the hypopharynx
27 November 2013 (online)
Endoscopic submucosal dissection (ESD) in the pharyngeal region is considered difficult. When ESD is carried out transorally for a tumor in the pharynx, the patient must be sedated . However, we have carried out, without sedation, ESD with a transnasal endoscope and our novel endoscopic attachment hood for this area. There is evidence that our method may be associated with reduced incidence of hemorrhage and perforation . Here, we report on the use of ESD in the treatment of pharyngeal dysplasia.
We have recently developed an attachment hood (TOP-16561, Nanoshooter) with a waterjet channel as well a suction channel for removing the residual water from the hood ([Fig. 1]), which we use with a transnasal endoscope (EG-530N2, Fujifilm, Tokyo, Japan; this is the only transnasal endoscope that can be used with a high-frequency electrosurgical system). The dysplastic lesion appeared as a brownish area, and irregular vessels were evident with a narrow-band imaging optical zoom endoscope ([Fig. 2]). We used our original precutting knife for resection and ICC200 (ERBE USA, Marietta, Georgia, USA) with the conventional settings. Without use of sedation, the endoscope with the Nanoshooter attached to it was inserted transnasally and a 1 : 1 mixture of lidocaine and 0.4 % hyaluronic acid  was injected submucosally ([Fig. 3]). After lifting the lesion, complete resection was carried out. After resecting the mucosal layer and trimming around the lesion, we used a snare to resect the lesion, reducing the procedure time ([Fig. 4]) to approximately 30 minutes in total ([Video 1]).
Pharyngeal ESD was easily carried out with our method because the pharynx could be directly observed from straight ahead. Moreover, the procedure was done without sedation and with causing little pain to the patient. This method shows potential for esophageal ESD. In the near future, it will be possible to use this treatment method with the Nanoshooter to enable transnasal ESD, without sedation, for neoplasms of the upper gastrointestinal tract in elderly and high-risk patients with cardiopulmonary disease.
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