Rhodium-Catalyzed Oxidative Coupling of Aryl Hydrazones with Internal Alkynes: Efficient Synthesis of Multisubstituted Isoquinolines

Wenting Liu; Xiaohu Hong; Bin Xu

doi:10.1055/s-0033-1338417

Synthesis, Inhaltsverzeichnis

Synthesis 2013; 45(15): 2137-2149
DOI: 10.1055/s-0033-1338417

special topic

Rhodium-Catalyzed Oxidative Coupling of Aryl Hydrazones with Internal Alkynes: Efficient Synthesis of Multisubstituted Isoquinolines

Wenting Liu

^aDepartment of Chemistry, Shanghai University, Shanghai 200444, P. R. of China Fax: +86(21)66134594 eMail: xubin@shu.edu.cn

,

Xiaohu Hong

^aDepartment of Chemistry, Shanghai University, Shanghai 200444, P. R. of China Fax: +86(21)66134594 eMail: xubin@shu.edu.cn

,

Bin Xu*

^aDepartment of Chemistry, Shanghai University, Shanghai 200444, P. R. of China Fax: +86(21)66134594 eMail: xubin@shu.edu.cn

^bState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. of China

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Abstract

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Abstract

An efficient rhodium-catalyzed oxidative coupling reaction has been developed that gives high yields of multisubstituted isoquinolines from easily accessible aryl hydrazones and internal alkynes. Indenone hydrazone can also be synthesized in high yield from the corresponding benzaldehyde hydrazone by using this approach.

Key words

alkynes - cyclization - hydrazones - heterocycles - rhodium - catalysis

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Referenzen

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