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Am J Perinatol 2013; 30(09): 781-786
DOI: 10.1055/s-0032-1333405
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Randomized Controlled Trial of the Effect of 30% versus 80% Fraction of Inspired Oxygen on Cesarean Delivery Surgical Site Infection

Ned L. Williams
1   Departments of Obstetrics and Gynecology, Wright State University and Miami Valley Hospital, Dayton, Ohio
2   United States Air Force, Wright-Patterson AFB, Ohio
,
Melanie M. Glover
1   Departments of Obstetrics and Gynecology, Wright State University and Miami Valley Hospital, Dayton, Ohio
,
Catrina Crisp
1   Departments of Obstetrics and Gynecology, Wright State University and Miami Valley Hospital, Dayton, Ohio
,
Angus L. Acton
1   Departments of Obstetrics and Gynecology, Wright State University and Miami Valley Hospital, Dayton, Ohio
,
David S. Mckenna
1   Departments of Obstetrics and Gynecology, Wright State University and Miami Valley Hospital, Dayton, Ohio
› Author Affiliations
Further Information

Publication History

21 May 2012

30 October 2012

Publication Date:
28 January 2013 (online)

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Abstract

Objective To determine if supplemental perioperative oxygen will reduce surgical site infection (SSI) following cesarean delivery.

Methods This is a randomized, controlled trial evaluating SSI following either 30% or 80% fraction of inspired oxygen (Fio 2) during and 2 hours after cesarean delivery. Anesthesia providers administered Fio 2 via a high-flow oxygen blender. Subjects, surgeons, and wound evaluation teams were blinded. Serial wound evaluations were performed. Data were analyzed using logistic regression models, Fisher exact test, and t test.

Results In all, 179 women were randomized, and 160 subjects were included in the analysis. There were 12/83 (14.5%) SSIs in the control group versus 10/77 (13.0%) in the investigational group (p = 0.82). Caucasian race, increased body mass index, and longer operative time were identified as significant risk factors for infection (p = 0.026, odds ratio 0.283; p = 0.05, odds ratio = 1.058; p = 0.037, odds ratio = 1.038, respectively).

Conclusion Perioperative oxygenation with 80% Fio 2 is not effective in reducing SSI following cesarean delivery.

Keywords

cesarean - Fio 2 - infection - surgical - oxygen

Source

Original prospective research performed at Miami Valley Hospital (MVH), Dayton, Ohio.


 

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