Pharmacopsychiatry 2013; 46(04): 151-155
DOI: 10.1055/s-0032-1333236
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Association of Ethnicity with Antipsychotic Dosage Using STRUCTURE Analysis

A. Hassan
1  CAMH, Department of Psychiatry, University of Toronto, Toronto, Canada
2  King Abdulaziz University, Jeddah, Saudi Arabia
,
C. Teo
1  CAMH, Department of Psychiatry, University of Toronto, Toronto, Canada
,
J.L. Kennedy
1  CAMH, Department of Psychiatry, University of Toronto, Toronto, Canada
,
A. Ravindran
1  CAMH, Department of Psychiatry, University of Toronto, Toronto, Canada
,
V. De Luca
1  CAMH, Department of Psychiatry, University of Toronto, Toronto, Canada
› Author Affiliations
Further Information

Publication History

received 09 September 2012
revised 02 December 2012

accepted 11 December 2012

Publication Date:
28 January 2013 (online)

Abstract

Introduction:

Several studies have examined whether ethnicity as an independent factor can influence the individual’s dosage of antipsychotics. However, there has been inconsistency in the results of these studies, particularly between white and non-white populations. This retrospective study tests the hypothesis of different dosing of antipsychotics in white Europeans vs. non-white Europeans considering both the self-reported ethnicity and the geographical ancestry calculated using 196 DNA markers.

Methods:

We collected self-reported ethnicity and DNA samples from 209 schizophrenia patients. We tested the association between self-reported and genetically-determined ethnicity with the chlorpromazine equivalent dose of each antipsychotic prescribed at the time of the assessment.

Results:

We did not find any significant difference between self-reported white European ­ethnicity and chlorpromazine equivalent doses (p=0.972). Furthermore, when we considered the geographical ancestry determined by the 196 SNPs, we could not find any correlation between the European ancestry and chlorpromazine equivalent dose.

Discussion:

Our preliminary analysis shows that there is no evidence that different ethnic groups receive different dose of antipsychotics.