Thorac Cardiovasc Surg 2013; 61(01): 022-028
DOI: 10.1055/s-0032-1331841
Original Cardiovascular
Georg Thieme Verlag KG Stuttgart · New York

Cardiac Surgery in Dialysis-Dependent Patients: Impact of Gender on Early Outcome in Single-Center Experience with 204 Consecutive Cases

Oliver Deutsch
1   Department of Cardiac Surgery, Clinic Bogenhausen, City Hospital Munich, Munich, Germany
,
Kyriakos Spiliopoulos
2   Department of Thoracic and Cardiovascular Surgery, University of Thessaly School of Medicine, Larissa, Greece
,
Theodor Kiask
1   Department of Cardiac Surgery, Clinic Bogenhausen, City Hospital Munich, Munich, Germany
,
Elpiniki Katsari
3   Klinik für Herz- Thorax- und Gefäßchirurgie, Klinikum Karlsburg, Karlsburg, Germany
,
Nathalie Rippinger
1   Department of Cardiac Surgery, Clinic Bogenhausen, City Hospital Munich, Munich, Germany
,
Walter Eichinger
1   Department of Cardiac Surgery, Clinic Bogenhausen, City Hospital Munich, Munich, Germany
,
Birgitte Gansera
1   Department of Cardiac Surgery, Clinic Bogenhausen, City Hospital Munich, Munich, Germany
› Author Affiliations
Further Information

Publication History

15 May 2012

23 October 2012

Publication Date:
10 January 2013 (online)

Abstract

Background This study evaluates the impact of gender in dialysis-dependent patients undergoing cardiac surgery.

Methods We retrospectively identified 204 dialysis-dependent patients (68.6% male, aged 66.6 ± 9.9 years) with end-stage renal disease undergoing cardiac surgery and compared them to a propensity-score-pair-matched control collective.

Results A 30-day mortality was 13.2% (14/106) for coronary artery bypass grafting (CABG), 19.3% (6/31) for aortic valve replacement (AVR), and 23.8% (16/67) for combined procedures. Postoperative chest tube output was significantly higher in men (1,007 ± 946 mL) versus women (687 ± 598 mL, p = 0.014). Compared with a propensity-score-pair-matched control collective of 204 patients, we identified significant differences in terms of 30-day mortality: overall mortality revealed 17.6 versus 4.6% (p = 0.0001), 13.2 versus 3.4% (p = 0.014) for CABG, 19.3 versus 0% (p = 0.051) for AVR, and 23.8 versus 9.1% (p = 0.02) for combined procedures.

Conclusion Multivariate analysis identified preoperative myocardial infarction, prolonged extracorporeal circulation time, operation time, and surgical reexploration as independent predictors of 30-day mortality. There was a higher occurrence of bleeding complications in men that remained significant even after correction for body surface area.

 
  • References

  • 1 Gansera B, Gillrath G, Lieber M, Angelis I, Schmidtler F, Kemkes BM. Are men treated better than women? Outcome of male versus female patients after CABG using bilateral internal thoracic arteries. Thorac Cardiovasc Surg 2004; 52 (5) 261-267
  • 2 Butterworth J, James R, Prielipp R, Cerese J, Livingston J, Burnett D. CABG Clinical Benchmarking Database Participants. Female gender associates with increased duration of intubation and length of stay after coronary artery surgery. Anesthesiology 2000; 92 (2) 414-424
  • 3 Koch CG, Weng YS, Zhou SX , et al., Ischemia Research and Education Foundation; Multicenter Study of Perioperative Ischemia Research Group. Prevalence of risk factors, and not gender per se, determines short- and long-term survival after coronary artery bypass surgery. J Cardiothorac Vasc Anesth 2003; 17 (5) 585-593
  • 4 Mosteller RD. Simplified calculation of body-surface area. N Engl J Med 1987; 317 (17) 1098
  • 5 Bonita R, Beaglehole R. Recovery of motor function after stroke. Stroke 1988; 19 (12) 1497-1500
  • 6 Gesundheitsberichterstattung des Bundes. www.gbe-bund.de 2006 . Ref Type: Online Source
  • 7 US Renal Data System. USRDS 2006 Annual Data Report: atlas of end-stage renal disease in the United States. National Institute of Health, National Institute of Diabetes and Digestive and Kidney Disease. 2006. Ref Type: Report
  • 8 Sarnak MJ, Levey AS, Schoolwerth AC , et al; American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Circulation 2003; 108 (17) 2154-2169
  • 9 Vaccarino V, Abramson JL, Veledar E, Weintraub WS. Sex differences in hospital mortality after coronary artery bypass surgery: evidence for a higher mortality in younger women. Circulation 2002; 105 (10) 1176-1181
  • 10 Reinecke H, Roeder N, Schmid C , et al. Outcome of women is impaired in patients undergoing emergency coronary artery bypass grafting for failed PTCA. Z Kardiol 2001; 90 (10) 729-736
  • 11 O'Connor GT, Morton JR, Diehl MJ , et al; The Northern New England Cardiovascular Disease Study Group. Differences between men and women in hospital mortality associated with coronary artery bypass graft surgery. Circulation 1993; 88 (5 Pt 1) 2104-2110
  • 12 Koch CG, Nussmeier NA. Gender and cardiac surgery. Anesthesiol Clin North America 2003; 21 (3) 675-689
  • 13 Kurlansky PA, Traad EA, Galbut DL, Singer S, Zucker M, Ebra G. Coronary bypass surgery in women: a long-term comparative study of quality of life after bilateral internal mammary artery grafting in men and women. Ann Thorac Surg 2002; 74 (5) 1517-1525
  • 14 Horst M, Mehlhorn U, Hoerstrup SP, Suedkamp M, de Vivie ER. Cardiac surgery in patients with end-stage renal disease: 10-year experience. Ann Thorac Surg 2000; 69 (1) 96-101
  • 15 Ariyoshi T, Eishi K, Yamachika S , et al. Perioperative and mid-term results of coronary bypass surgery in patients undergoing chronic dialysis. Ann Thorac Cardiovasc Surg 2006; 12 (4) 257-264
  • 16 Bechtel JF, Detter C, Fischlein T , et al. Cardiac surgery in patients on dialysis: decreased 30-day mortality, unchanged overall survival. Ann Thorac Surg 2008; 85 (1) 147-153
  • 17 Boku N, Masuda M, Eto M, Nishida T, Morita S, Tominaga R. Risk evaluation and midterm outcome of cardiac surgery in patients on dialysis. Asian Cardiovasc Thorac Ann 2007; 15 (1) 19-23
  • 18 Filsoufi F, Rahmanian PB, Castillo JG, Silvay G, Carpentier A, Adams DH. Predictors and early and late outcomes of dialysis-dependent patients in contemporary cardiac surgery. J Cardiothorac Vasc Anesth 2008; 22 (4) 522-529
  • 19 Gultekin B, Ozkan S, Uguz E , et al. Valve replacement surgery in patients with end-stage renal disease: long-term results. Artif Organs 2005; 29 (12) 972-975
  • 20 Horai T, Fukui T, Tabata M, Takanashi S. Early and mid-term results of off-pump coronary artery bypass grafting in patients with end stage renal disease: surgical outcomes after achievement of complete revascularization. Interact Cardiovasc Thorac Surg 2008; 7 (2) 218-221
  • 21 Jault F, Rama A, Bonnet N , et al. Cardiac surgery in patients receiving long term hemodialysis. Short and long term results. J Cardiovasc Surg (Torino) 2003; 44 (6) 725-730
  • 22 Kato W, Tajima K, Terasawa S, Tanaka K, Usui A, Ueda Y. Results of isolated valve replacement in hemodialysis patients. Asian Cardiovasc Thorac Ann 2007; 15 (5) 386-391
  • 23 Kogan A, Medalion B, Kornowski R , et al. Cardiac surgery in patients on chronic hemodialysis: short and long-term survival. Thorac Cardiovasc Surg 2008; 56 (3) 123-127
  • 24 Krabatsch T, Yeter R, Hetzer R. Coronary surgery in patients requiring chronic hemodialysis. Kidney Blood Press Res 2005; 28 (5–6) 270-274
  • 25 Luciani N, Nasso G, D'Alessandro C , et al. [Heart surgery interventions in chronic dialysis patients: short- and long-term results]. Ital Heart J Suppl 2002; 3 (7) 746-752
  • 26 Nicolini F, Fragnito C, Molardi A , et al. Heart surgery in patients on chronic dialysis: is there still room for improvement in early and long-term outcome?. Heart Vessels 2011; 26 (1) 46-54
  • 27 Rahmanian PB, Adams DH, Castillo JG, Vassalotti J, Filsoufi F. Early and late outcome of cardiac surgery in dialysis-dependent patients: single-center experience with 245 consecutive patients. J Thorac Cardiovasc Surg 2008; 135 (4) 915-922
  • 28 Toole JM, Stroud MR, Kratz JM, Crumbley III AJ, Crawford Jr FA, Ikonomidis JS. Valve surgery in renal dialysis patients. J Heart Valve Dis 2006; 15 (3) 453-458 , discussion 458
  • 29 Tugtekin S, Kappert U, Jarny K , et al. Coronary surgery in dialysis-dependent patients with end-stage renal failure with and without extracorporeal circulation. Thorac Cardiovasc Surg 2007; 55 (2) 84-88
  • 30 Jahangiri M, Wright J, Edmondson S, Magee P. Coronary artery bypass graft surgery in dialysis patients. Heart 1997; 78 (4) 343-345
  • 31 Nakayama Y, Sakata R, Ura M. Bilateral internal thoracic artery use for dialysis patients: does it increase operative risk?. Ann Thorac Surg 2001; 71 (3) 783-787
  • 32 Kai M, Okabayashi H, Hanyu M , et al. Long-term results of bilateral internal thoracic artery grafting in dialysis patients. Ann Thorac Surg 2007; 83 (5) 1666-1671
  • 33 Kinoshita T, Asai T, Murakami Y , et al. Bilateral versus single internal thoracic artery grafting in dialysis patients with multivessel disease. Heart Surg Forum 2010; 13 (5) E280-E286
  • 34 Kinoshita T, Asai T, Hosoba S , et al. Does off-pump bilateral internal thoracic artery grafting increase operative risk in dialysis patients?. Heart Surg Forum 2010; 13 (2) E74-E79
  • 35 Gansera B, Schmidtler F, Gillrath G , et al. Does bilateral ITA grafting increase perioperative complications? Outcome of 4462 patients with bilateral versus 4204 patients with single ITA bypass. Eur J Cardiothorac Surg 2006; 30 (2) 318-323
  • 36 Liu JY, Birkmeyer NJ, Sanders JH , et al. ; Northern New England Cardiovascular Disease Study Group. Risks of morbidity and mortality in dialysis patients undergoing coronary artery bypass surgery. Circulation 2000; 102 (24) 2973-2977
  • 37 Miyahara K, Maeda M, Sakurai H, Nakayama M, Murayama H, Hasegawa H. Cardiovascular surgery in patients on chronic dialysis: effect of intraoperative hemodialysis. Interact Cardiovasc Thorac Surg 2004; 3 (1) 148-152
  • 38 Tugtekin SM, Alexiou K, Georgi Ch, Kappert U, Knaut M, Matschke K. Coronary surgery in dialysis-dependent patients with end stage renal failure. Z Kardiol 2005; 94 (10) 679-683
  • 39 Milani R, Brofman PR, Souza JA , et al. OPCAB in patients on hemodialysis. Rev Bras Cir Cardiovasc 2007; 22 (1) 104-108, discussion 108–110
  • 40 Deutsch E, Bernstein RC, Addonizio P, Kussmaul III WG. Coronary artery bypass surgery in patients on chronic hemodialysis. A case-control study. Ann Intern Med 1989; 110 (5) 369-372