Repeated Measures of Placental Growth Factor, Placental Protein 13, and A Disintegrin and Metalloprotease 12 at First and Second Trimesters for Preeclampsia Screening

Isabelle Boucoiran; Eva Suarthana; Evelyne Rey; Edgard Delvin; William B. Fraser; François Audibert

doi:10.1055/s-0032-1331025

American Journal of Perinatology, Table of Contents

Am J Perinatol 2013; 30(08): 681-688
DOI: 10.1055/s-0032-1331025

Original Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Repeated Measures of Placental Growth Factor, Placental Protein 13, and A Disintegrin and Metalloprotease 12 at First and Second Trimesters for Preeclampsia Screening

Isabelle Boucoiran

¹Department of Obstetrics and Gynecology, CHU Sainte-Justine Research Center, Université de Montréal, Montreal, Quebec, Canada

,

Eva Suarthana

²Department of Preventive Medicine, Research Center of Sacré-Coeur Hospital, Université de Montréal, Montréal, Québec, Canada

,

Evelyne Rey

¹Department of Obstetrics and Gynecology, CHU Sainte-Justine Research Center, Université de Montréal, Montreal, Quebec, Canada

,

Edgard Delvin

³Department of Clinical Biochemistry, CHU Sainte-Justine Research Center, Université de Montréal, Montreal, Quebec, Canada

,

William B. Fraser

¹Department of Obstetrics and Gynecology, CHU Sainte-Justine Research Center, Université de Montréal, Montreal, Quebec, Canada

,

François Audibert

¹Department of Obstetrics and Gynecology, CHU Sainte-Justine Research Center, Université de Montréal, Montreal, Quebec, Canada

› Author Affiliations

Abstract

Objective To determine the utility of cross-trimester repeated measures of placental protein 13 (PP13), A disintegrin and metalloprotease 12 (ADAM12), and placental growth factor (PlGF) for preeclampsia (PE) screening.

Study Design A prospective cohort study of 893 nulliparous women who had serum sampling at 11 to 14 and 18 to 22 weeks. Biomarker levels were adjusted on maternal characteristics and gestational age. The accuracy and validity of maternal characteristics with single and repeated markers to predict PE were evaluated.

Results First-trimester PlGF was the best biomarker for PE (mean: 0.85 multiples of the expected median [MoM]) and early onset PE (0.79 MoM). First-trimester screening performances were not significantly improved by second-trimester markers. Area under the receiver operating characteristic curve was 0.73 (95% confidence interval [CI] 0.65 to 0.81) with first-trimester PlGF and 0.71 (95% CI 0.63 to 0.80) with first- and second-trimester PlGF (p = 0.301).

Conclusion Repeated measures of PlGF, ADAM12, and PP13 at second trimester did not improve PE screening compared with first-trimester measures.

Keywords

preeclampsia - screening - PlGF - PP13 - ADAM12

Full Text

References

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