Am J Perinatol 2013; 30(03): 215-218
DOI: 10.1055/s-0032-1323582
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

The Effect of Phototherapy on Fecal Calprotectin Levels

Aysegul Bukulmez
1   Faculty of Medicine, Department of Pediatrics, Afyon Kocatepe University, Afyonkarahisar, Turkey
,
Omer Dogru
2   Department of Pediatric Hematology, Medical Park Göztepe Hospital, Istanbul, Turkey
,
Ahmet Afsin Kundak
3   Department of Pediatrics, Sami Ulus Maternity, Children's Education and Research Hospital, Ankara, Turkey
,
Osman Oztekin
4   Faculty of Medicine, Department of Pediatrics, Akdeniz University, Antalya, Turkey
,
Resit Koken
4   Faculty of Medicine, Department of Pediatrics, Akdeniz University, Antalya, Turkey
,
Hamide Melek
5   Faculty of Medicine, Department of Pediatrics, Uludağ University, Bursa, Turkey
,
Fahri Ovali
6   Department of Pediatrics, Zeynep Kamil Maternity and Children's Education and Training Hospital, Istanbul, Turkey
,
Tulay Koken
7   Faculty of Medicine, Department of Biochemistry, Afyon Kocatepe University, Afyonkarahisar, Turkey
› Author Affiliations
Further Information

Publication History

09 February 2012

06 April 2012

Publication Date:
08 August 2012 (online)

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Abstract

Objective Fetal calprotectin levels increase in the early stages of necrotizing enterocolitis. Although the effects of several factors on fetal calprotectin have been studied, the effect of phototherapy is not known. In this study, we analyzed the effect of phototherapy on fetal calprotectin levels.

Methods Ninety breast-fed newborns (46 male, 44 female) who were hospitalized for indirect hyperbilirubinemia and treated with phototherapy were included to the study. Forty-two of them were term and 44 of them were preterm. Newborns treated with phototherapy (n = 53) constituted the phototherapy group (29 preterm, 24 term) and 37 newborns who did not receive phototherapy (19 preterm, 18 term) constituted the control group. Fecal samples were collected 24 hours after phototherapy had been started. Fecal samples (100 mg) were weighed with sensitive scales and preserved at −80°C after buffering with a special solution. All samples were studied at the same time with a fecal calprotectin kit by using enzyme-linked immunosorbent assay.

Results There were no statistically significant difference between fecal calprotectin levels of term and preterm babies who received phototherapy and babies who did not receive phototherapy.

Conclusion There was no effect of 24-hour phototherapy on fecal calprotectin levels in preterm and term newborns.