Download PDF
Endoskopie heute 2012; 25(2): 145-154
DOI: 10.1055/s-0032-1312968
Leitlinie
© Georg Thieme Verlag KG Stuttgart · New York

Kolonkapselendoskopie: Leitlinie der Europäischen Gesellschaft für Gastrointestinale Endoskopie

Colon Capsule Endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Guideline
C. Spada
1   Digestive Endoscopy Unit, Catholic University, Rome, Italy
,
C. Hassan
2   Department of Gastroenterology and Hepatology, Nantes, University, Nantes, France
,
J. P. Galmiche
3   Department of Gastroenterology, Evangelisches Krankenhaus, Düsseldorf, Germany
,
H. Neuhaus
4   Service of Gastroenterology and Hepatology, Geneva University Hospitals, Geneva, Switzerland
,
J. M. Dumonceau
5   Department of Gastroenterology, Bikur Holim Hospital; Jerusalem, Israel
,
S. Adler
6   Department of Gastroenterology, Royal Free and University College Medical School, London, UK
,
O. Epstein
7   Department of Hepato-Gastroenterology, HU Strasbourg, Strasbourg, France
,
G. Gay
8   Division of Gastroenterology 2, San Giovanni Battista University Teaching Hospital, Turin, Italy
,
M. Pennazio
9   Department of Gastroenterology, Indiana University Hospital, Indianapolis, USA
,
D. K. Rex
10   Department of Gastroenterology, Avienne Hospital, University of Paris, Bobigny, France
,
R. Benamouzig
11   Gastroenterology Unit, Luigi Sacco University Hospital, Milan, Italy
,
R. de Franchis
12   Department of Gastroenterology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium
,
M. Delvaux
13   Chaim Sheba Medical Center, Tel-Aviv, Israel
,
J. Devière
14   Department of Gastroenterology, St. Mark’s Hospital, London, UK
,
R. Eliakim
15   Department of Medicine I, Altona General Hospital, Hamburg, Germany
,
C. Fraser
16   Gastroenterology Service, Virgen Macarena University Hospital, Seville, Spain
,
F. Hagenmuller
17   Clinic for Internal Medicine, Bethesda Krankenhaus Bergedorf, Hamburg, Germany
,
J. M. Herrerias
18   Department of Gastroenterology and Clinical Nutrition Service, Royal Melbourne Hospital, Melbourne, Australia
,
M. Keuchel
19   Digestive Endoscopy Unit, Clinica Universitaria de Navarra, Pamplona, Spain
,
F. Macrae
20   Department of Gastroenterology, Hospital Edouard Herriot, Lyon, France
,
M. Munoz-Navas
21   Department of Gastroenterology, Hospital Universitario de Canarias, Tenerife, Spain
,
T. Ponchon
22   Gastroenterology Unit, Ospedale Valdue, Como, Italy
,
E. Quintero
23   Division of Gastroenterology, Curto Hospital, Polla, Italy
,
M. E. Riccioni
24   Department of Medicine and Therapeutics, Division of Gastroenterology, Prince of Wales Hospital, Shatin, N.T, Hong Kong
,
E. Rondonotti
25   Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
,
R. Marmo
26   Endoscopy Unit, Skane University Hospital, Lund University, Malmö, Sweden
,
J. J. Sung
27   Hepatogastroenterology Unit, 2nd department of Internal Medicine-Propaedeutic, Attikon University General Hospital, Athens University, Athens, Greece
,
H. Tajiri
27   Hepatogastroenterology Unit, 2nd department of Internal Medicine-Propaedeutic, Attikon University General Hospital, Athens University, Athens, Greece
,
E. Toth
27   Hepatogastroenterology Unit, 2nd department of Internal Medicine-Propaedeutic, Attikon University General Hospital, Athens University, Athens, Greece
,
K. Triantafyllou
27   Hepatogastroenterology Unit, 2nd department of Internal Medicine-Propaedeutic, Attikon University General Hospital, Athens University, Athens, Greece
,
A. Van Gossum
27   Hepatogastroenterology Unit, 2nd department of Internal Medicine-Propaedeutic, Attikon University General Hospital, Athens University, Athens, Greece
,
G. Costamagna
27   Hepatogastroenterology Unit, 2nd department of Internal Medicine-Propaedeutic, Attikon University General Hospital, Athens University, Athens, Greece
› Author Affiliations
Further Information

Publication History

Publication Date:
03 July 2012 (online)

Also available at
    Permissions and Reprints

Zusammenfassung

Die Pillcam-Kolonkapselendoskopie (CCE) ist eine innovative, nicht invasive peroral applizierbare Kapseltechnik, die die Untersuchung des Kolons ohne Sedierung und Gasinsufflation ermöglicht. Obwohl sie in Europa und anderen Ländern bereits verfügbar ist, sind die klinischen Indikationen der CCE, die Befundung und das Vorgehen bei detektierten Veränderungen bisher nicht standardisiert. Das Ziel dieser evidenzbasierten, konsensuellen Leitlinie, die von der Europäischen Gesellschaft für Gastrointestinale Endoskopie (ESGE) in Auftrag gegeben worden ist, ist es, Anbieter im Gesundheitssystem mit einem umfassenden Rahmen für die potenzielle Implementierung dieser Technik in klinische Abläufe auszustatten.

Abstract

PillCam colon capsule endoscopy (CCE) is an innovative noninvasive, and painless ingestible capsule technique that allows exploration of the colon without the need for sedation and gas insufflation. Although it is already available in European and other countries, the clinical indications for CCE as well as the reporting and work-up of detected findings have not yet been standardized. The aim of this evidence-based and consensus-based guideline, commissioned by the European Society of Gastrointestinal Endoscopy (ESGE) is to furnish healthcare providers with a comprehensive framework for potential implementation of this technique in a clinical setting.

Schlüsselwörter

Kolonkapselendoskopie - Indikationen - Kontraindikationen - Darmvorbereitung - kolorektales Karzinom - Screening - chronisch-entzündliche Darmerkrankungen

Key words

colon capsule endoscopy - indications - contraindications - bowel preparation - colorectal Cancer - screening - inflammatory bowel disease
 

  • Literatur

  • 1 Ferlay J, Autier P, Boniol M et al. Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol 2007; 18: 581-592
    CrossrefPubMedGoogle Scholar
  • 2 Atkin WS, Edwards R, Kralj-Hans I et al. Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial. Lancet 2010; 375 (9726) 1624-1633
    CrossrefPubMedGoogle Scholar
  • 3 Winawer SJ, Zauber AG, Ho MN et al. Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup. N Engl J Med 1993; 329: 1977-1981
    CrossrefPubMedGoogle Scholar
  • 4 Citarda F, Tomaselli G, Capocaccia R et al. Efficacy in standard clinical practice of colonoscopic polypectomy in reducing colorectal cancer incidence. Gut 2001; 48: 812-815
    CrossrefPubMedGoogle Scholar
  • 5 Segnan N, Senore C, Andreoni B et al. Comparing attendance and detection rate of colonoscopy with sigmoidoscopy and FIT for colorectal cancer screening. Gastroenterology 2007; 132: 2304-2312
    CrossrefPubMedGoogle Scholar
  • 6 Lisi D, Hassan C, Crespi M et al. Participation to colorectal cancer screening with FOBT and colonoscopy: An Italian, multicentre, randomized population study. Dig Liver Dis 2010; 42: 371-376
    CrossrefPubMedGoogle Scholar
  • 7 Eliakim R, Fireman Z, Gralnek IM et al. Evaluation of the PillCam Colon capsule in the detection of colonic pathology: results of the first multicenter, prospective, comparative study. Endoscopy 2006; 38: 963-970
    Article in Thieme ConnectPubMedGoogle Scholar
  • 8 Schoofs N, Devière J, Van Gossum A et al. PillCam colon capsule endoscopy compared with colonoscopy for colorectal tumor diagnosis: a prospective pilot study. Endoscopy 2006; 38: 971-977
    Article in Thieme ConnectPubMedGoogle Scholar
  • 9 Van Gossum A, Navas MM, Fernandez-Urien I et al. Capsule endoscopy versus colonoscopy for the detection of polyps and cancer. N Engl J Med 2009; 361: 264-270
    CrossrefPubMedGoogle Scholar
  • 10 Sieg A, Friedrich K, Sieg U et al. Is PillCam COLON capsule endoscopy ready for colorectal cancer screening? A prospective feasibility study in a community gastroenterology practice. Am J Gastroenterol 2009; 104: 848-854
    CrossrefPubMedGoogle Scholar
  • 11 Gay G, Delvaux M, Frederic M et al. Could the colonic capsule PillCam Colon be clinically useful for selecting patients who deserve a complete colonoscopy? Results of clinical comparison with colonoscopy in the perspective of colorectal cancer screening. Am J Gastroenterol 2010; 105: 1076-1086
    CrossrefPubMedGoogle Scholar
  • 12 Sacher-Huvelin S, Coron E, Gaudric M et al. Colon capsule endoscopy vs. colonoscopy in patients at average or increased risk of colorectal cancer. Aliment Pharmacol Ther 2010; 32: 1145-1153
    CrossrefPubMedGoogle Scholar
  • 13 Pilz JB, Portmann S, Peter S et al. Colon capsule endoscopy compared to conventional colonoscopy under routine screening conditions. BMC Gastroenterol 2010; ਜ 10: 66
    CrossrefPubMedGoogle Scholar
  • 14 Spada C, Riccioni ME, Hassan C et al. PillCam colon capsule endoscopy: a prospective, randomized trial comparing two regimens of preparation. J Clin Gastroenterol 2011; 45: 119-124
    CrossrefPubMedGoogle Scholar
  • 15 Spada C, Hassan C, Ingrosso M et al. A new regimen of bowel preparation for PillCam colon capsule endoscopy: a pilot study. Dig Liver Dis 2011; 43: 300-304
    CrossrefPubMedGoogle Scholar
  • 16 Spada C, Hassan C, Marmo R et al. Meta-analysis shows colon capsule endoscopy is effective in detecting colorectal polyps. Clin Gastroenterol Hepatol 2010; 8: 516-522
    CrossrefPubMedGoogle Scholar
  • 17 Rokkas T, Papaxoinis K, Triantafyllou K et al. A meta-analysis evaluating the accuracy of colon capsule endoscopy in detecting colon polyps. Gastrointest Endosc 2010; 71: 792-798
    CrossrefPubMedGoogle Scholar
  • 18 Eliakim R, Yassin K, Niv Y et al. Prospective multicenter performance evaluation of the second-generation colon capsule compared with colonoscopy. Endoscopy 2009; 41: 1026-1031
    Article in Thieme ConnectPubMedGoogle Scholar
  • 19 Spada C, Hassan C, Riccioni ME et al. False positive at colon capsule endoscopy or false negative at conventional colonoscopy?. Endoscopy 2010; 42: 427-428
    Article in Thieme ConnectPubMedGoogle Scholar
  • 20 Spada C, Hassan C, Munoz-Navas M et al. Second-generation colon capsule compared with colonoscopy. Gastrointest Endosc 2011; 74: 581-589
    CrossrefPubMedGoogle Scholar
  • 21 Dumonceau JM, Andriulli A, Deviere J et al. European Society of Gastrointestinal Endoscopy (ESGE) Guideline: prophylaxis of post-ERCP pancreatitis. Endoscopy 2010; 42: 503-515
    Article in Thieme ConnectPubMedGoogle Scholar
  • 22 Harbour R, Miller J. A new system for grading recommendations in evidence based guidelines. BMJ 2001; 323: 334-336
    PubMedGoogle Scholar
  • 23 Johnson CD, Chen MH, Toledano AY et al. Accuracy of CT colonography for detection of large adenomas and cancers. N Engl J Med 2008; 359: 1207-1217
    CrossrefPubMedGoogle Scholar
  • 24 Hundt S, Haug U, Brenner H. Comparative evaluation of immunochemical fecal occult blood tests for colorectal adenoma detection. Ann Intern Med 2009; 150: 162-169
    CrossrefPubMedGoogle Scholar
  • 25 Levin B, Lieberman DA, McFarland B et al. Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology. Gastroenterology 2008; 134: 1570-1595
    CrossrefPubMedGoogle Scholar
  • 26 Lieberman DA. Clinical practice. Screening for colorectal cancer. N Engl J Med 2009; 361: 1179-1187
    CrossrefPubMedGoogle Scholar
  • 27 Hassan C, Zullo A, Winn S et al. Cost-effectiveness of capsule endoscopy in screening for colorectal cancer. Endoscopy 2008; 40: 414-421
    Article in Thieme ConnectPubMedGoogle Scholar
  • 28 Rex DK, Mark D, Clarke B et al. Flexible sigmoidoscopy plus air-contrast barium enema versus colonoscopy for evaluation of symptomatic patients without evidence of bleeding. Gastrointest Endosc 1995; 42: 132-138
    CrossrefPubMedGoogle Scholar
  • 29 Pickhardt PJ, Choi JR, Hwang I et al. Computed tomographic virtual colonoscopy to screen for colorectal neoplasia in asymptomatic adults. N Engl J Med 2003; 349: 2191-2200
    CrossrefPubMedGoogle Scholar
  • 30 Goulston KJ, Cook I, Dent OF. How important is rectal bleeding in the diagnosis of bowel cancer and polyps?. Lancet 1986; 2: 261-265
    PubMedGoogle Scholar
  • 31 American Society for Gastrointestinal Endoscopy. Appropriate use of gastrointestinal endoscopy. Gastrointest Endosc 2000; 52: 831-837
    CrossrefPubMedGoogle Scholar
  • 32 Bowles CJ, Leicester R, Romaya C et al. A prospective study of colonoscopy practice in the UK today: are we adequately prepared for national colorectal cancer screening tomorrow?. Gut 2004; 53: 277-283
    CrossrefPubMedGoogle Scholar
  • 33 Lieberman DA, Weiss DG, Bond JH et al. Use of colonoscopy to screen asymptomatic adults for colorectal cancer. Veterans Affairs Cooperative Study Group 380. N Engl J Med 2000; 343: 162-168
    CrossrefPubMedGoogle Scholar
  • 34 Rex DK. Achieving cecal intubation in the very difficult colon. Gastrointest Endosc 2008; 67: 938-944
    CrossrefPubMedGoogle Scholar
  • 35 Hanson ME, Pickhardt PJ, Kim DH et al. Anatomic factors predictive of incomplete colonoscopy based on findings at CT colonography. Am J Roentgenol 2007; 189: 774-779
    CrossrefPubMedGoogle Scholar
  • 36 Spada C, Riccioni ME, Petruzziello L et al. The new PillCam Colon capsule: difficult colonoscopy? No longer a problem?. Gastrointest Endosc 2008; 68: 807-808
    CrossrefPubMedGoogle Scholar
  • 37 Triantafyllou K, Tsibouris P, Kalantzis C et al. PillCam Colon capsule endoscopy does not always complement incomplete colonoscopy. Gastrointest Endosc 2009; 69: 572-576
    CrossrefPubMedGoogle Scholar
  • 38 Triantafyllou K, Viazis N, Tsibouris P et al. Colon capsule endoscopy complements incomplete colonoscopy in clinical practice. Endoscopy 2010; 42 (Suppl. 01) A27
    Article in Thieme ConnectPubMedGoogle Scholar
  • 39 Abraham C, Cho JH. Inflammatory bowel disease. N Engl J Med 2009; 361: 2066-2078
    CrossrefPubMedGoogle Scholar
  • 40 Bourreille A, Ignjatovic A, Aabakken L et al. Role of small-bowel endoscopy in the management of patients with inflammatory bowel disease: an international OMED-ECCO consensus. Endoscopy 2009; 41: 618-637
    Article in Thieme ConnectPubMedGoogle Scholar
  • 41 Strange EF, Travis SPL, Vermeire S et al. European evidence-based Consensus on the diagnosis and management of ulcerative colitis: Definitions and diagnosis. J Crohn’s Colitis 2008; 2: 1-23
    PubMedGoogle Scholar
  • 42 Lichtenstein GR, Rutgeerts P. Importance of mucosal healing in ulcerative colitis. Inflamm Bowel Dis 2010; 16: 338-346
    CrossrefPubMedGoogle Scholar
  • 43 D’Haens GR, Panaccione R, Higgins PD et al. The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD with the European Crohn’s and Colitis Organization: when to start, when to stop, which drug to choose, and how to predict response?. Am J Gastroenterol 2011; 106: 199-212
    CrossrefPubMedGoogle Scholar
  • 44 Sung JJY, Ching JY, Leung WK et al. Assessment of colonic inflammatory lesions and ulcerative colitis with PillCam Colon capsule endoscopy compared to colonoscopy. Endoscopy 2008; 40: A199
    Article in Thieme ConnectPubMedGoogle Scholar
  • 45 Ladas SD, Triantafyllou K, Spada C et al. European Society of Gastrointestinal Endoscopy (ESGE): recommendations (2009) on clinical use of video capsule endoscopy to investigate small-bowel, esophageal and colonic diseases. Endoscopy 2010; 42: 220-227
    Article in Thieme ConnectPubMedGoogle Scholar
  • 46 US Food and Drugs Administration. Oral sodium phosphate (OSP) products for bowel cleansing (marketed as Visicol and OsmoPrep, and oral sodium phosphate products available without a prescription). Available at: www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm103354.htm Accessed: 11 March 2011
    PubMedGoogle Scholar
  • 47 Rácz I, Jánoki M, Saleh H. Colon cancer detection by “rendezvous colonoscopy”: successful removal of stuck colon capsule by conventional colonoscopy. Case Rep Gastroenterol 2010; 4: 19-24
    CrossrefPubMedGoogle Scholar
  • 48 Kakugawa Y, Saito Y, Saito S et al. Evaluation of newly modified bowel preparation method as a less invasive procedure in conducting colon capsule endoscopy. ICCD Proceedings, Paris, August 27–28 2010 [abstract]
    PubMedGoogle Scholar
  • 49 Marmo R, Rotondano G, Riccio G et al. Effective bowel cleansing before colonoscopy: a randomized study of split-dosage versus non-split dosage regimens of high-volume versus low-volume polyethylene glycol solutions. Gastrointest Endosc 2010; 72: 313-320
    CrossrefPubMedGoogle Scholar
  • 50 Segarajasingam DS, Pawlik J, Forbes GM. Informed consent in direct access colonoscopy. J Gastroenterol Hepatol 2007; 22: 2081-2085
    CrossrefPubMedGoogle Scholar
  • 51 Leighton J, Rex D. A grading scale to evaluate colon cleansing for the PillCam COLON capsule: a reliability study. Endoscopy 2011; 43: 123-127
    Article in Thieme ConnectPubMedGoogle Scholar
  • 52 Lieberman D, Moravec M, Holub J et al. Polyp size and advanced histology in patients undergoing colonoscopy screening: Implications for CT colonography. Gastroenterology 2008; 135: 1100-1105
    CrossrefPubMedGoogle Scholar
  • 53 Bond JH. Clinical relevance of the small colorectal polyp. Endoscopy 2001; 33: 454-457
    Article in Thieme ConnectPubMedGoogle Scholar
  • 54 Church JM. Clinical significance of small colorectal polyps. Dis Colon Rectum 2004; 47: 481-485
    CrossrefPubMedGoogle Scholar
  • 55 Hassan C, Pickhardt PJ, Kim DH et al. Systematic review: Distribution of advanced neoplasia according to polyp size at screening colonoscopy. Aliment Pharmacol Ther 2010; 31: 210-217
    PubMedGoogle Scholar
  • 56 Weston AP, Campbell DR. Diminutive colonic polyps: histopathology, spatial distribution, concomitant significant lesions, and treatment complications. Am J Gastroenterol 1995; 90: 24-28
    PubMedGoogle Scholar
  • 57 van Rijn JC, Reitsma JB, Stoker J et al. Polyp miss rate determined by tandem colonoscopy: a systematic review. Am J Gastroenterol 2006; 10: 343-350
    PubMedGoogle Scholar
  • 58 Rex DK, Cutler CS, Lemmel GT et al. Colonoscopic miss rates of adenomas determined by back to back colonoscopies. Gastroenterology 1997; 112: 24-28
    CrossrefPubMedGoogle Scholar
  • 59 Pickhardt PJ, Hassan C, Laghi A et al. Cost-effectiveness of colorectal cancer screening with computed tomography colonography – the impact of not reporting diminutive lesions. Cancer 2007; 109: 2213-2221
    CrossrefPubMedGoogle Scholar
  • 60 Pickhardt PJ, Hassan C, Laghi H et al. Small and diminutive polyps detected at screening CT colonography: a decision analysis for referral to colonoscopy. Am J Roentgenol 2008; 190: 136-144
    CrossrefPubMedGoogle Scholar
  • 61 Martínez ME, Baron JA, Lieberman DA et al. A pooled analysis of advanced colorectal neoplasia diagnoses after colonoscopic polypectomy. Gastroenterology 2009; 136: 832-841
    CrossrefPubMedGoogle Scholar
  • 62 Hoff G, Foerster A, Vatn MH et al. Epidemiology of polyps in the rectum and colon. Recovery and evaluation of unresected polyps 2 years after detection. Scand J Gastroenterol 1986; 21: 853-862
    CrossrefPubMedGoogle Scholar
  • 63 Hofstad B, Vatn MH, Andersen SN et al. Growth of colorectal polyps: redetection and evaluation of unresected polyps for a period of three years. Gut 1996; 39: 449-456
    CrossrefPubMedGoogle Scholar
  • 64 Pickhardt PJ, Hassan C, Laghi A et al. Clinical management of small (6- to 9-mm) polyps detected at screening CT colonography: a cost-effectiveness analysis. Am J Roentgenol 2008; 191: 1509-1516
    CrossrefPubMedGoogle Scholar
  • 65 The Paris endoscopic classification of superficial neoplastic lesions: esophagus, stomach, and colon: November 30 to December 1, 2002. Gastrointest Endosc 2003; 58: S3-S43
    CrossrefPubMedGoogle Scholar
  • 66 Hsu CW, Imperiale TF. Meta-analysis and cost comparison of polyethylene glycol lavage versus sodium phosphate for colonoscopy preparation. Gastrointest Endosc 1998; 48: 276-282
    CrossrefPubMedGoogle Scholar
  • 67 Belsey J, Epstein O, Heresbach D. Systematic review: oral bowel preparation for colonoscopy. Aliment Pharmacol Ther 2007; 25: 373-384
    CrossrefPubMedGoogle Scholar
  • 68 Ness RM, Manam R, Hoen H et al. Predictors of inadequate bowel preparation for colonoscopy. Am J Gastroenterol 2001; 96: 1797-1802
    CrossrefPubMedGoogle Scholar