Sleep Disorders in Chronic Liver Disease

Sharon De Cruz; Joseph Roland D. Espiritu; Michelle Zeidler; Tisha S. Wang

doi:10.1055/s-0032-1301732

Seminars in Respiratory and Critical Care Medicine, Inhaltsverzeichnis

Semin Respir Crit Care Med 2012; 33(01): 26-35
DOI: 10.1055/s-0032-1301732

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Sleep Disorders in Chronic Liver Disease

Sharon De Cruz

¹Division of Pulmonary, Critical Care, and Sleep Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California.

,

Joseph Roland D. Espiritu

²Division of Pulmonary, Critical Care, and Sleep Medicine, St. Louis University School of Medicine, St. Louis, Missouri.

,

Michelle Zeidler

¹Division of Pulmonary, Critical Care, and Sleep Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California.

,

Tisha S. Wang

¹Division of Pulmonary, Critical Care, and Sleep Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California.

› Institutsangaben

Abstract

Sleep-related complaints and disturbances are increasingly recognized in the setting of chronic liver disease and have recently been shown to be an important prognostic factor in patients with advanced chronic liver disease. This article reviews the literature surrounding sleep disturbances and disorders in a variety of types of chronic liver disease. This includes the association of sleep disturbances with hepatitis C and antiviral therapy, primary biliary cirrhosis, and Wilson disease as well as the circadian rhythm abnormalities present in cirrhosis and hepatic encephalopathy. The association between chronic liver disease, particularly nonalcoholic fatty liver disease, and sleep-disordered breathing is also reviewed in detail.

Keywords

sleep apnea - hepatic cirrhosis - electroencephalogram - polysomnogram - circadian rhythm

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Referenzen

References
1 Montagnese S, Middleton B, Skene DJ, Morgan MY. Night-time sleep disturbance does not correlate with neuropsychiatric impairment in patients with cirrhosis. Liver Int 2009; 29 (9) 1372-1382
2 Tarter RE, Hegedus AM, Van Thiel DH, Schade RR, Gavaler JS, Starzl TE. Nonalcoholic cirrhosis associated with neuropsychological dysfunction in the absence of overt evidence of hepatic encephalopathy. Gastroenterology 1984; 86 (6) 1421-1427
3 Córdoba J, Cabrera J, Lataif L, Penev P, Zee P, Blei AT. High prevalence of sleep disturbance in cirrhosis. Hepatology 1998; 27 (2) 339-345
4 Mostacci B, Ferlisi M, Baldi Antognini A , et al. Sleep disturbance and daytime sleepiness in patients with cirrhosis: a case control study. Neurol Sci 2008; 29 (4) 237-240
5 Jiménez-Anguiano A, Díaz-Medina V, Farfán-Labonne BE , et al. Modification of sleep architecture in an animal model of experimental cirrhosis. World J Gastroenterol 2009; 15 (41) 5176-5180
6 Kanwal F, Gralnek IM, Hays RD , et al. Health-related quality of life predicts mortality in patients with advanced chronic liver disease. Clin Gastroenterol Hepatol 2009; 7 (7) 793-799
7 Sherlock S, Summerskill WH, White LP, Phear EA. Portal-systemic encephalopathy; neurological complications of liver disease. Lancet 1954; 267 (6836) 454-457
8 Papenberg J, Lanzinger G, Kommerell B, Hoyer S. Comparative studies of the electroencephalogram and the cerebral oxidative metabolism in patients with liver cirrhosis. Klin Wochenschr 1975; 53 (23) 1107-1113
9 Butterworth RF. Complications of cirrhosis, III: Hepatic encephalopathy. J Hepatol 2000; 32 (1, Suppl) 171-180
10 Hazell AS, Butterworth RF. Hepatic encephalopathy: an update of pathophysiologic mechanisms. Proc Soc Exp Biol Med 1999; 222 (2) 99-112
11 Bergeron M, Reader TA, Layrargues GP, Butterworth RF. Monoamines and metabolites in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy. Neurochem Res 1989; 14 (9) 853-859
12 Rose C, Felipo V. Limited capacity for ammonia removal by brain in chronic liver failure: potential role of nitric oxide. Metab Brain Dis 2005; 20 (4) 275-283
13 Bahn E, Nolte W, Kurth C, Ramadori G, Rüther E, Wiltfang J. Quantification of the electroencephalographic theta/alpha ratio for the assessment of portal-systemic encephalopathy following implantation of transjugular intrahepatic portosystemic stent shunt (TIPSS). Metab Brain Dis 2002; 17 (1) 19-28
14 Bismuth M, Funakoshi N, Cadranel JF, Blanc P. Hepatic encephalopathy: from pathophysiology to therapeutic management. Eur J Gastroenterol Hepatol 2011; 23 (1) 8-22
15 Kaplan PW. The EEG in metabolic encephalopathy and coma. J Clin Neurophysiol 2004; 21 (5) 307-318
16 Martino ME, Romero-Vives M, Fernández-Lorente J, De Vicente E, Bárcena R, Gaztelu JM. Sleep electroencephalogram alterations disclose initial stage of encephalopathy. Methods Find Exp Clin Pharmacol 2002; 24 (Suppl D) 119-122
17 Hourmand-Ollivier I, Piquet MA, Toudic JP, Denise P, Dao T. Actigraphy: a new diagnostic tool for hepatic encephalopathy. World J Gastroenterol 2006; 12 (14) 2243-2244
18 Zee PC, Mehta R, Turek FW, Blei AT. Portacaval anastomosis disrupts circadian locomotor activity and pineal melatonin rhythms in rats. Brain Res 1991; 560 (1-2) 17-22
19 Steindl PE, Finn B, Bendok B, Rothke S, Zee PC, Blei AT. Disruption of the diurnal rhythm of plasma melatonin in cirrhosis. Ann Intern Med 1995; 123 (4) 274-277
20 Møller S, Wiinberg N, Hernriksen JH. Noninvasive 24-hour ambulatory arterial blood pressure monitoring in cirrhosis. Hepatology 1995; 22 (1) 88-95
21 Alvarez D, Golombek D, Lopez P , et al. Diurnal fluctuations of portal and systemic hemodynamic parameters in patients with cirrhosis. Hepatology 1994; 20 (5) 1198-1203
22 García-Pagán JC, Feu F, Castells A , et al. Circadian variations of portal pressure and variceal hemorrhage in patients with cirrhosis. Hepatology 1994; 19 (3) 595-601
23 Bernardi M, Trevisani F, De Palma R , et al. Chronobiological evaluation of sympathoadrenergic function in cirrhosis: relationship with arterial pressure and heart rate. Gastroenterology 1987; 93 (6) 1178-1186
24 Kerkhof GA, Korving HJ, Willemse-vd Geest HM, Rietveld WJ. Diurnal differences between morning-type and evening-type subjects in self-rated alertness, body temperature and the visual and auditory evoked potential. Neurosci Lett 1980; 16 (1) 11-15
25 Kerkhof GA. Inter-individual differences in the human circadian system: a review. Biol Psychol 1985; 20 (2) 83-112
26 Mullen KD, McCullough AJ. Problems with animal models of chronic liver disease: suggestions for improvement in standardization. Hepatology 1989; 9 (3) 500-503
27 Velissaris D, Karanikolas M, Kalogeropoulos A , et al. Pituitary hormone circadian rhythm alterations in cirrhosis patients with subclinical hepatic encephalopathy. World J Gastroenterol 2008; 14 (26) 4190-4195
28 Montagnese S, Middleton B, Mani AR, Skene DJ, Morgan MY. Sleep and circadian abnormalities in patients with cirrhosis: features of delayed sleep phase syndrome?. Metab Brain Dis 2009; 24 (3) 427-439
29 Montagnese S, Middleton B, Mani AR, Skene DJ, Morgan MY. On the origin and the consequences of circadian abnormalities in patients with cirrhosis. Am J Gastroenterol 2010; 105 (8) 1773-1781
30 Reichenbach A, Fuchs U, Kasper M, el-Hifnawi E, Eckstein AK. Hepatic retinopathy: morphological features of retinal glial (Müller) cells accompanying hepatic failure. Acta Neuropathol 1995; 90 (3) 273-281
31 Wagner DR. Circadian rhythm sleep disorders. In: Thorpy MJ, , ed. Handbook of Sleep Disorders. New York: Dekker; 1990: 493-525
32 Steindl PE, Coy DL, Finn B, Zee PC, Blei AT. A low-protein diet ameliorates disrupted diurnal locomotor activity in rats after portacaval anastomosis. Am J Physiol 1996; 271 (4 Pt 1) G555-G560
33 Jones DE, Al-Rifai A, Frith J, Patanwala I, Newton JL. The independent effects of fatigue and UDCA therapy on mortality in primary biliary cirrhosis: results of a 9. year follow-up. J Hepatol 2010; 53 (5) 911-917
34 Cauch-Dudek K, Abbey S, Stewart DE, Heathcote EJ. Fatigue in primary biliary cirrhosis. Gut 1998; 43 (5) 705-710
35 Poupon RE, Chrétien Y, Chazouillères O, Poupon R, Chwalow J. Quality of life in patients with primary biliary cirrhosis. Hepatology 2004; 40 (2) 489-494
36 Prince MI, James OF, Holland NP, Jones DE. Validation of a fatigue impact score in primary biliary cirrhosis: towards a standard for clinical and trial use. J Hepatol 2000; 32 (3) 368-373
37 Newton JL, Gibson GJ, Tomlinson M, Wilton K, Jones D. Fatigue in primary biliary cirrhosis is associated with excessive daytime somnolence. Hepatology 2006; 44 (1) 91-98
38 Forton DM, Patel N, Prince M , et al. Fatigue and primary biliary cirrhosis: association of globus pallidus magnetisation transfer ratio measurements with fatigue severity and blood manganese levels. Gut 2004; 53 (4) 587-592
39 Mastorakos G, Chrousos GP, Weber JS. Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans. J Clin Endocrinol Metab 1993; 77 (6) 1690-1694
40 Martinez OM, Villanueva JC, Gershwin ME, Krams SM. Cytokine patterns and cytotoxic mediators in primary biliary cirrhosis. Hepatology 1995; 21 (1) 113-119
41 Nagano T, Yamamoto K, Matsumoto S , et al. Cytokine profile in the liver of primary biliary cirrhosis. J Clin Immunol 1999; 19 (6) 422-427
42 Vgontzas AN, Papanicolaou DA, Bixler EO, Kales A, Tyson K, Chrousos GP. Elevation of plasma cytokines in disorders of excessive daytime sleepiness: role of sleep disturbance and obesity. J Clin Endocrinol Metab 1997; 82 (5) 1313-1316
43 Kaplan MM, Bonis PA. Modafinil for the treatment of fatigue in primary biliary cirrhosis. Ann Intern Med 2005; 143 (7) 546-547
44 Jones DE, Newton JL. An open study of modafinil for the treatment of daytime somnolence and fatigue in primary biliary cirrhosis. Aliment Pharmacol Ther 2007; 25 (4) 471-476
45 Ian Gan S, de Jongh M, Kaplan MM. Modafinil in the treatment of debilitating fatigue in primary biliary cirrhosis: a clinical experience. Dig Dis Sci 2009; 54 (10) 2242-2246
46 Hardy T, MacDonald C, Jones DE, Newton JL. A follow-up study of modafinil for the treatment of daytime somnolence and fatigue in primary biliary cirrhosis. Liver Int 2010; 30 (10) 1551-1552
47 Global Burden Of Hepatitis C Working Group. Global burden of disease (GBD) for hepatitis C. J Clin Pharmacol 2004; 44 (1) 20-29
48 Lee DH, Jamal H, Regenstein FG, Perrillo RP. Morbidity of chronic hepatitis C as seen in a tertiary care medical center. Dig Dis Sci 1997; 42 (1) 186-191
49 Sockalingam S, Abbey SE, Alosaimi F, Novak M. A review of sleep disturbance in hepatitis C. J Clin Gastroenterol 2010; 44 (1) 38-45
50 Carlson MD, Hilsabeck RC, Barakat F, Perry W. Role of sleep disturbance in chronic hepatitis C infection. Curr Hepat Rep 2010; 9 (1) 25-29
51 Raison CL, Rye DB, Woolwine BJ , et al. Chronic interferon-alpha administration disrupts sleep continuity and depth in patients with hepatitis C: association with fatigue, motor slowing, and increased evening cortisol. Biol Psychiatry 2010; 68 (10) 942-949
52 de Almeida CM, de Lima TA, Castro DB , et al. Immunological/virological peripheral blood biomarkers and distinct patterns of sleeping quality in chronic hepatitis C patients. Scand J Immunol 2011; 73 (5) 486-495
53 Rabkin JG, McElhiney MC, Rabkin R. Modafinil and armodafinil treatment for fatigue for HIV-positive patients with and without chronic hepatitis C. Int J STD AIDS 2011; 22 (2) 95-101
54 Martin KA, Krahn LE, Balan V, Rosati MJ. Modafinil's use in combating interferon-induced fatigue. Dig Dis Sci 2007; 52 (4) 893-896
55 Tanzi RE, Petrukhin K, Chernov I , et al. The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene. Nat Genet 1993; 5 (4) 344-350
56 Bull PC, Thomas GR, Rommens JM, Forbes JR, Cox DW. The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene. Nat Genet 1993; 5 (4) 327-337
57 Portala K, Westermark K, von Knorring L, Ekselius L. Psychopathology in treated Wilson's disease determined by means of CPRS expert and self-ratings. Acta Psychiatr Scand 2000; 101 (2) 104-109
58 Firneisz G, Szalay F, Halasz P, Komoly S. Hypersomnia in Wilson's disease: an unusual symptom in an unusual case. Acta Neurol Scand 2000; 101 (4) 286-288
59 Portala K, Westermark K, Ekselius L, Broman JE. Sleep in patients with treated Wilson's disease: a questionnaire study. Nord J Psychiatry 2002; 56 (4) 291-297
60 Spisni E, Valerii MC, Manerba M , et al. Effect of copper on extracellular levels of key pro-inflammatory molecules in hypothalamic GN11 and primary neurons. Neurotoxicology 2009; 30 (4) 605-612
61 Barthel H, Hermann W, Kluge R , et al. Concordant pre- and postsynaptic deficits of dopaminergic neurotransmission in neurologic Wilson disease. AJNR Am J Neuroradiol 2003; 24 (2) 234-238
62 Gagnon JF, Bédard MA, Fantini ML , et al. REM sleep behavior disorder and REM sleep without atonia in Parkinson's disease. Neurology 2002; 59 (4) 585-589
63 Baumann C, Ferini-Strambi L, Waldvogel D, Werth E, Bassetti CL. Parkinsonism with excessive daytime sleepiness—a narcolepsy-like disorder?. J Neurol 2005; 252 (2) 139-145
64 Nevsimalova S, Buskova J, Bruha R , et al. Sleep disorders in Wilson's disease. Eur J Neurol 2011; 18 (1) 184-190
65 Netto AB, Sinha S, Taly AB, Panda S, Rao S. Sleep in Wilson's disease: questionnaire based study. Ann Indian Acad Neurol 2011; 14 (1) 31-34
66 Netto AB, Sinha S, Taly AB, Panda S, Rao S. Sleep in Wilson's disease: a polysomnography-based study. Neurol India 2010; 58 (6) 933-938
67 Crespo J, Cifrián J, Pinto JA, Jiménez-Gómez A, Pons-Romero F. Sleep apnea obstructive syndrome: a new complication previously undescribed in cirrhotic patients with ascites. Am J Gastroenterol 2003; 98 (12) 2815-2816
68 Golpe R, Mateos A. Obstructive sleep apnea: a complication in cirrhotic patients with ascites?. Am J Gastroenterol 2005; 100 (6) 1421-1423, author reply 1423
69 Nikaina I, Pastaka C, Zachou K, Dalekos GN, Gourgoulianis K. Sleep apnoea syndrome and early stage cirrhosis: a pilot study. Eur J Gastroenterol Hepatol 2006; 18 (1) 31-35
70 Ogata T, Nomura M, Nakaya Y, Ito S. Evaluation of episodes of sleep apnea in patients with liver cirrhosis. J Med Invest 2006; 53 (1-2) 159-166
71 Madias NE, Adrogue H. Respiratory alkalosis. In: Dubose TD, Hamm LL, , eds. Acid–Base and Electrolyte Disorders. Philadelphia: WB Saunders; 2002: 147-163
72 Javaheri S, Almoosa KF, Saleh K, Mendenhall CL. Hypocapnia is not a predictor of central sleep apnea in patients with cirrhosis. Am J Respir Crit Care Med 2005; 171 (8) 908-911
73 Gami AS, Caples SM, Somers VK. Obesity and obstructive sleep apnea. Endocrinol Metab Clin North Am 2003; 32 (4) 869-894
74 Lavie L, Vishnevsky A, Lavie P. Evidence for lipid peroxidation in obstructive sleep apnea. Sleep 2004; 27 (1) 123-128
75 Ahmed MH, Byrne CD. Obstructive sleep apnea syndrome and fatty liver: association or causal link?. World J Gastroenterol 2010; 16 (34) 4243-4252
76 Singh H, Pollock R, Uhanova J, Kryger M, Hawkins K, Minuk GY. Symptoms of obstructive sleep apnea in patients with nonalcoholic fatty liver disease. Dig Dis Sci 2005; 50 (12) 2338-2343
77 Savransky V, Nanayakkara A, Vivero A , et al. Chronic intermittent hypoxia predisposes to liver injury. Hepatology 2007; 45 (4) 1007-1013
78 Savransky V, Bevans S, Nanayakkara A , et al. Chronic intermittent hypoxia causes hepatitis in a mouse model of diet-induced fatty liver. Am J Physiol Gastrointest Liver Physiol 2007; 293 (4) G871-G877
79 Takayama F, Egashira T, Kawasaki H , et al. A novel animal model of nonalcoholic steatohepatitis (NASH): hypoxemia enhances the development of NASH. J Clin Biochem Nutr 2009; 45 (3) 335-340
80 Chin K, Nakamura T, Takahashi K , et al. Effects of obstructive sleep apnea syndrome on serum aminotransferase levels in obese patients. Am J Med 2003; 114 (5) 370-376
81 Shpirer I, Copel L, Broide E, Elizur A. Continuous positive airway pressure improves sleep apnea associated fatty liver. Lung 2010; 188 (4) 301-307
82 Kohler M, Pepperell JC, Davies RJ, Stradling JR. Continuous positive airway pressure and liver enzymes in obstructive sleep apnoea: data from a randomized controlled trial. Respiration 2009; 78 (2) 141-146
83 Tanné F, Gagnadoux F, Chazouillères O , et al. Chronic liver injury during obstructive sleep apnea. Hepatology 2005; 41 (6) 1290-1296
84 Kheirandish-Gozal L, Sans Capdevila O, Kheirandish E, Gozal D. Elevated serum aminotransferase levels in children at risk for obstructive sleep apnea. Chest 2008; 133 (1) 92-99
85 Tian JL, Zhang Y, Chen BY. Sleep apnea hypopnea syndrome and liver injury. Chin Med J (Engl) 2010; 123 (1) 89-94
86 Piguet AC, Stroka D, Zimmermann A, Dufour JF. Hypoxia aggravates non-alcoholic steatohepatitis in mice lacking hepatocellular PTEN. Clin Sci (Lond) 2010; 118 (6) 401-410
87 Byrne CD. Hypoxia and non-alcoholic fatty liver disease. Clin Sci (Lond) 2010; 118 (6) 397-400
88 Kallwitz ER, Herdegen J, Madura J, Jakate S, Cotler SJ. Liver enzymes and histology in obese patients with obstructive sleep apnea. J Clin Gastroenterol 2007; 41 (10) 918-921
89 Polotsky VY, Patil SP, Savransky V , et al. Obstructive sleep apnea, insulin resistance, and steatohepatitis in severe obesity. Am J Respir Crit Care Med 2009; 179 (3) 228-234
90 Mishra P, Nugent C, Afendy A , et al. Apnoeic-hypopnoeic episodes during obstructive sleep apnoea are associated with histological nonalcoholic steatohepatitis. Liver Int 2008; 28 (8) 1080-1086
91 Jouët P, Sabaté JM, Maillard D , et al. Relationship between obstructive sleep apnea and liver abnormalities in morbidly obese patients: a prospective study. Obes Surg 2007; 17 (4) 478-485
92 Daltro C, Cotrim HP, Alves E , et al. Nonalcoholic fatty liver disease associated with obstructive sleep apnea: just a coincidence?. Obes Surg 2010; 20 (11) 1536-1543
93 Norman D, Bardwell WA, Arosemena F , et al. Serum aminotransferase levels are associated with markers of hypoxia in patients with obstructive sleep apnea. Sleep 2008; 31 (1) 121-126
94 Tatsumi K, Saibara T. Effects of obstructive sleep apnea syndrome on hepatic steatosis and nonalcoholic steatohepatitis. Hepatol Res 2005; 33 (2) 100-104
95 Douglas NJ, White DP, Pickett CK, Weil JV, Zwillich CW. Respiration during sleep in normal man. Thorax 1982; 37 (11) 840-844
96 Bradley TD, Phillipson EA. Sleep disorders. In: Murray JF, Nadel JA, Mason RJ, , eds. Textbook of Respiratory Medicine. Philadelphia, PA: WB Saunders; 2000: 2153-2169
97 Palma DT, Philips GM, Arguedas MR, Harding SM, Fallon MB. Oxygen desaturation during sleep in hepatopulmonary syndrome. Hepatology 2008; 47 (4) 1257-1263
98 Halank M, Langner S, Kolditz M, Miehlke S, Höffken G. Nocturnal oxygen desaturation is a frequent complication in portopulmonary hypertension. Z Gastroenterol 2008; 46 (11) 1260-1265
99 Salas RE, Gamaldo CE, Allen RP. Update in restless legs syndrome. Curr Opin Neurol 2010; 23 (4) 401-406
100 Franco RA, Ashwathnarayan R, Deshpandee A , et al. The high prevalence of restless legs syndrome symptoms in liver disease in an academic-based hepatology practice. J Clin Sleep Med 2008; 4 (1) 45-49
101 Tembl JI, Ferrer JM, Sevilla MT, Lago A, Mayordomo F, Vilchez JJ. Neurologic complications associated with hepatitis C virus infection. Neurology 1999; 53 (4) 861-864
102 LaRochelle JS, Karp BI. Restless legs syndrome due to interferon-alpha. Mov Disord 2004; 19 (6) 730-731
103 Adam R, Lucidi V, Karam V. Liver transplantation in Europe: is there a room for improvement?. J Hepatol 2005; 42 (1) 33-40
104 Gelling L. Quality of life following liver transplantation: physical and functional recovery. J Adv Nurs 1998; 28 (4) 779-785
105 Tarter RE, Van Thiel DH, Hegedus AM, Schade RR, Gavaler JS, Starzl TE. Neuropsychiatric status after liver transplantation. J Lab Clin Med 1984; 103 (5) 776-782
106 van den Berg-Emons R, van Ginneken B, Wijffels M , et al. Fatigue is a major problem after liver transplantation. Liver Transpl 2006; 12 (6) 928-933
107 van Ginneken BT, van den Berg-Emons RJ, van der Windt A , et al. Persistent fatigue in liver transplant recipients: a two-year follow-up study. Clin Transplant 2010; 24 (1) E10-E16
108 Aadahl M, Hansen BA, Kirkegaard P, Groenvold M. Fatigue and physical function after orthotopic liver transplantation. Liver Transpl 2002; 8 (3) 251-259
109 Rodrigue JR, Nelson DR, Reed AI, Hanto DW, Curry M. Fatigue and sleep quality before and after liver transplantation. Prog Transplant 2010; 20 (3) 221-233
110 Cordoba J, Steindl P, Blei AT. Melatonin arrhythmia is corrected after liver transplantation. Am J Gastroenterol 2009; 104 (7) 1862-1863