Arzneimittelforschung 2007; 57(10): 641-646
DOI: 10.1055/s-0031-1296662
Cardiac Drugs · Cardiac Stimulants · Coronary Drugs
Editio Cantor Verlag Aulendorf (Germany)

Synthesis and Bioactivity of 6-Phenyl-4,5-dihydro-3(2H)-pyridazinone Derivatives

Teng Wang
1  Department of Organic Chemistry, China Pharmaceutical University, Nanjing, China
,
Ying Dong
1  Department of Organic Chemistry, China Pharmaceutical University, Nanjing, China
,
Li-Chen Wang
1  Department of Organic Chemistry, China Pharmaceutical University, Nanjing, China
,
Zhen Chen
2  Department of Pharmacology, China Pharmaceutical University, Nanjing, China
› Author Affiliations
Further Information

Publication History

Publication Date:
21 December 2011 (online)

Abstract

A series of 6-phenyl-4,5-dihydro-3(2H)-pyridazinone derivatives was prepared and examined for cardiotonic activity. The structures of these new pyridazinone derivatives were confirmed by IR, 1H-NMR and mass spectrum. The cardiotonic activities of these compounds were studied on isolated perfused toad heart and compared with the activity of levosimendan (CAS 141505-33-1). Compound 5a emerged as the most interesting compound in this series with potential car-diotonic activity.