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Arzneimittelforschung 2007; 57(10): 641-646
DOI: 10.1055/s-0031-1296662
DOI: 10.1055/s-0031-1296662
Cardiac Drugs · Cardiac Stimulants · Coronary Drugs
Synthesis and Bioactivity of 6-Phenyl-4,5-dihydro-3(2H)-pyridazinone Derivatives
Further Information
Publication History
Publication Date:
21 December 2011 (online)
Abstract
A series of 6-phenyl-4,5-dihydro-3(2H)-pyridazinone derivatives was prepared and examined for cardiotonic activity. The structures of these new pyridazinone derivatives were confirmed by IR, 1H-NMR and mass spectrum. The cardiotonic activities of these compounds were studied on isolated perfused toad heart and compared with the activity of levosimendan (CAS 141505-33-1). Compound 5a emerged as the most interesting compound in this series with potential car-diotonic activity.