A series of chromonyl-2,4-thiazolidinediones (VIa-f) and chromonyl-2,4-imidazolidinediones (VIIa-f) was prepared by Knoevenagel reaction of substituted benzyl-2,4-thiazolidinediones (IVa-f) and substituted benzyl-2,4-imidazolidinediones (Va-f) with chromone-3-carboxaldehyde (I). The prepared compounds were tested for their insulinotropic activities in INS-1 cells. Compounds Va, VIb, Vd and VIIe (at lower concentration; 1 μg/ml) were able to increase insulin release in the presence of 5.6 mmol/l glucose; their effects were lower than that of glibenclamide (CAS 10238-21-8). The activity of the most potent compound (VId) was still 9 % less than that of glibenclamide.
Key words
Antidiabetic agents - Chromone - Chromonyl-2,4-thiazolidinediones, antidiabetic activity, synthesis - 2,4-Thiazolidinediones
