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Arzneimittelforschung 2007; 57(8): 532-536
DOI: 10.1055/s-0031-1296644
Antidiabetics
Editio Cantor Verlag Aulendorf (Germany)

Synthesis and Antidiabetic Activity of Some New Chromonyl-2,4-thiazo-lidinediones

Oya Bozdag-Dündar
1   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Tandoğan, Ankara, Turkey
,
Meltem Ceylan-Ünlüsoy
1   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Tandoğan, Ankara, Turkey
,
Eugen J. Verspohl
2   Department of Pharmacology, Institute of Medicinal Chemistry, Münster University, Münster, Germany
,
Rahmiye Ertan
1   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Tandoğan, Ankara, Turkey
› Author Affiliations
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Publication History

Publication Date:
21 December 2011 (online)

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Abstract

A series of chromonyl-2,4-thiazolidinediones (VIa-f) and chromonyl-2,4-imidazolidinediones (VIIa-f) was prepared by Knoevenagel reaction of substituted benzyl-2,4-thiazolidinediones (IVa-f) and substituted benzyl-2,4-imidazolidinediones (Va-f) with chromone-3-carboxaldehyde (I). The prepared compounds were tested for their insulinotropic activities in INS-1 cells. Compounds Va, VIb, Vd and VIIe (at lower concentration; 1 μg/ml) were able to increase insulin release in the presence of 5.6 mmol/l glucose; their effects were lower than that of glibenclamide (CAS 10238-21-8). The activity of the most potent compound (VId) was still 9 % less than that of glibenclamide.

Key words

Antidiabetic agents - Chromone - Chromonyl-2,4-thiazolidinediones, antidiabetic activity, synthesis - 2,4-Thiazolidinediones