Synthesis of 1,2,3-Triazole-Fused Heterocycles via Intramolecular Azide-Alkyne Cycloaddition Reactions

Abstract

This brief review article describes the progress made in the synthesis of 1,2,3-triazole-fused heterocycles, over the last ten years, mainly by azide-alkyne cycloaddition reactions. In this article, the emphasis is on the various aspects of 1,3-dipolar cycloaddition reactions, especially intramolecular azide-alkyne dipolar cycloaddition reactions.

1 Introduction

2 Synthesis of Fused Triazoles

2.1 Synthesis of 1,2,3-Triazole-Fused Heterocycles by Huisgen (Thermal) 1,3-Cycloaddition Reactions

2.2 Microwave-Assisted 1,3-Dipolar Cycloaddition Reactions for the Synthesis of Condensed Triazoles

2.3 Copper-Catalyzed Cycloaddition Reactions for the Synthesis of Condensed Triazoles

2.4 Copper/Other-Metal-Catalyzed Cycloaddition Reactions for the Synthesis of Condensed Triazoles

2.5 Synthesis of Triazole-Containing Macrocycles by Azide-Alkyne 1,3-Dipolar Cycloaddition Reactions

3 Conclusion

1,2,3-triazole - azide - alkyne - cycloaddition - heterocycles

References

<A NAME="RM39611SS-1">1</A>

Present address: Department of Chemical Sciences, Tezpur University, Napaam, Tezpur 784 028, Assam, India.

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