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Synfacts 2011(11): 1204-1204  
DOI: 10.1055/s-0031-1289221
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Pd-Catalyzed Chemo- and Regioselective Allylic Alkylation

Contributor(s): Mark Lautens, Lei Zhang
J.-P. Chen, Q. Peng, B.-L. Lei, X.-L. Hou*, Y.-D. Wu*
Shanghai Institute of Organic Chemistry, Peking University Shenzhen Graduate School, Beijing and The Hong Kong University of Science and Technology, Kowloon, P. R. of China
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Publikationsverlauf

Publikationsdatum:
19. Oktober 2011 (online)

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Significance

A tunable palladium-catalyzed allylic alkylation was realized. The authors propose that by changing the counterion of the base from Li+ to K+ the reaction became selective for branched products with high diastereoselectivity.