Synfacts 2011(11): 1220-1220  
DOI: 10.1055/s-0031-1289216
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

One-Pot Domino Ring Opening/C-N Bond Formations

Contributor(s): Mark Lautens, Hasnain A. Malik
M. K. Ghorai*, Y. Nanaji, A. K. Yadav
Indian Institute of Technology, Kanpur, India
Further Information

Publication History

Publication Date:
19 October 2011 (online)

Significance

Tetrahydroquinolines are biologically relevant molecules that have attracted a great deal of synthetic interest. While there are numerous methods of the construction of such structural motifs, the synthesis of enantiopure products from easily obtained chiral starting materials remains an attractive strategy. Furthermore, the synthesis of such compounds in a domino one-pot fashion is noteworthy and allows for ease of synthesis.