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Zeitschrift für Phytotherapie 2012; 33(1): 19-23
DOI: 10.1055/s-0031-1286040
Forschung
Urolithiasis
© Haug Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG

Efficacy of a fixed combination of Centaurii herba, Levistici radix and Rosmarini folium in urinary lithiasis

Results of an open randomised cohort study
Emil Ceban
Subject Editor:
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Publication History

Publication Date:
22 March 2012 (online)

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Zusammenfassung

Wirksamkeit eines Kombinationsarzneimittels aus Centaurii herba, Levistici radix und Rosmarini folium bei Urolithiasis: Ergebnisse einer offenen, randomisierten, Kohortenstudie

Urolithiasis (Harnsteinleiden; Bildung von Konkrementen in den ableitenden Harnwegen) kann zu schmerzhaften, kolikartigen Schmerzen führen, wenn die Konkremente oder Steine die Harnwege blockieren. Pflanzliche Drogenzubereitungen spielen seit Langem eine bedeutsame Rolle in der Prophylaxe und Therapie des Harnsteinleidens. In einigen Studien wurde bereits die Wirkung des Phytopharmakons Canephron® N, einer fixen Kombination der Drogen Centaurii herba, Levistici radix und Rosmarini folium, bei der Urolithiasis gezeigt. In einer aktuellen offenen, randomisierten, monozentrischen Kohortenstudie wurde die Therapie mit Canephron® N als Add-on-Therapie untersucht. Das Phytopharmakon wurde 135 Patienten zusätzlich zur Standardtherapie verabreicht, die Daten dieser Kohorte wurden mit den Daten von 102 Patienten unter Standardtherapie verglichen. Canephron® N begünstigte die spontane Elimination von Konkrementen und verminderte die Leukozyturie, die insbesondere mit entzündlichen Prozessen im Harntrakt einhergeht. Die Anwendung der Kombination zur Prävention und/oder als Add-on-Therapie in Ergänzung der Standardtherapie der Urolithiasis erscheint gerechtfertigt.

Summary

Urolithiasis describes the formation of calculi in kidney and efferent urinary passages. If these calculi jam urinary passages, it is often associated with typical spastic pain attacks. Certain herbal drugs play a special role in urolithiasis prophylaxis and treatment. The herbal medical product Canephron® N, a combination of Centaurii herba, Levistici radix and Rosmarini folium, is established in the therapy of urolithiasis, the indication is proven by some clinical studies. In a randomised open monocentric add-on cohort study, the efficacy of Canephron® N was investigated for the treatment of urolithiasis. The herbal medical product was administered in 135 patients additionally to standard therapy, for comparison 102 patients were treated with standard therapy only. Canephron® N favours the spontaneous elimination of small calculi and significantly decreases leucocyturia, especially associated with urinary infection. Therefore it is justified to suggest the combination for prevention and/or in addition to standard therapy of urolithiasis.

Key words

Urolithiasis - herbal therapy - Centaurium spp. - Levisticum officinale - Rosmarinus officinalis - open randomised cohort study - efficacy

Schlüsselwörter

Urolithiasis - Phytotherapie - Centaurium spp. - Levisticum officinale - Rosmarinus officinalis - offene randomisierte Kohortenstudie - Wirksamkeit
 

  • References

  • 1 Abdul-Ghani AS, El-Lati SG, Sacaan AI et al. Anticonvulsant effects of some Arab medicinal plants. Int J Crude Drug Res 1987; 25: 39-43
    PubMedGoogle Scholar
  • 2 Amosov AV. Herbal Canephron in urological practice. Doctors 2000; 6: 36
    PubMedGoogle Scholar
  • 3 Curhan GC, Rimm EB, Willett WC, Stampfer M. Regional variation in nephrolithiasis incidence and prevalence among United States men. J Urol 1994; 151: 838-841
    PubMedGoogle Scholar
  • 4 Davidov MI. Results of emergency ureterolithotomy and acoustic stimulation of the upper urinary tract. Current issues of clinical surgery. Permi 1993; 153-156
    PubMedGoogle Scholar
  • 5 Djavad-Zade MD. Ureteral stones; Indications for conservative and surgery treatment methods. Moscow: Medghiz; 1961: 98-109
    Google Scholar
  • 6 European Association of Urology. Guidelines on urolithiasis. Update March 2011 1-104 http://www.uroweb.org/gls/pdf/18_Urolithiasis.pdf
    Google Scholar
  • 7 European Scientific Cooperative on Phytotherapy (ESCOP). Centaurii herba (Centaury herb). In: ESCOP Monographs. 2nd ed. Stuttgart, New York: Thieme; 2003: 70-73
    Google Scholar
  • 8 European Scientific Cooperative on Phytotherapy (ESCOP). Rosmarini folium (Rosemary leaf). In: ESCOP Monographs. 2nd ed. Stuttgart, New York: Thieme; 2003: 429-436
    Google Scholar
  • 9 Geavlete Petrisor. Compendium of Urologic Pathology. Bucharest: Copertex S.R.L.; 1999: 203-256
    Google Scholar
  • 10 Gracza L, Koch H, Löffler E. Isolierung von Rosmarinsäure aus Symphytum officinale und ihre anti-inflammatorische Wirksamkeit in einem In-vitro-Modell. Arch Pharm 1985; 318: 1090-1095
    CrossrefPubMedGoogle Scholar
  • 11 Gusikov AR. Direct electric and acoustic stimulation of the upper urinary tract in the situation ureters stones. Doctoral thesis for medical sciences. Moscow 1985; 189
    PubMedGoogle Scholar
  • 12 Haloui M, Louedec L, Michel JB, Lyoussi B. Experimental diuretic effects of Rosmarinus officinalis and Centaurium erythraea. . J Ethnopharmacol 2000; 71: 465-472
    CrossrefPubMedGoogle Scholar
  • 13 Kovalenko VN. Compedium 2001/2002 – Medications. Kiev: Morion; 2001: 1536
    Google Scholar
  • 14 Kumarasamy Y, Nahar L, Cox PJ et al. Bioac-tivity of secoiridoid glycosides from Centaurium erythraea . Phytomedicine 2003; 10: 344-347
    CrossrefPubMedGoogle Scholar
  • 15 Kumarasamy Y, Nahar L, Sarker SD. Bioactivity of gentiopicroside from the aerial parts of Centaurium erythraea . Fitoterapia 2003; 74: 151-154
    CrossrefPubMedGoogle Scholar
  • 16 Lopatkin NA, Pugaceva AG. Pediatric urology guide. Moscow: 1986: 396
    Google Scholar
  • 17 Lopatkin NA. Manual of Urology. Vol. 2, ch. 29: Urolithiasis. Moscow: 1998: 693-761
    Google Scholar
  • 18 Piteli IUA, Amosov AV. Herbal Canephron in urological practice. Attending Doctor 1999; 6: 38-39
    PubMedGoogle Scholar
  • 19 Popescu Eugeniu I. Urologic Clinic. Urinary stones. Bucharest 1997: 141-161
    PubMed
  • 20 Rampart M, Beetens JR, Bult H et al. Complement-dependent stimulation of prostacyclin biosynthesis; inhibition by rosmarinic acid. Biochem Pharmacol 1986; 35: 1397-1400
    CrossrefPubMedGoogle Scholar
  • 21 Sinescu I, Gluck G. Treaty of Urology, Vol. II. Bucharest: 2008: 1063-1076
    Google Scholar
  • 22 Sinescu I. Urologic Clinic. Bucharest: 1998
    Google Scholar
  • 23 Sterner W, Heisler E, Popp HO, Fischer H. Studien überdie Canephron-Wirkung bei chronischen Nierenerkrankungen. Physika-lische Medizin und Rehabilitation 1973; 14: 239-258
    PubMedGoogle Scholar
  • 24 Tiktinski OL. Urolithiasis. Leningrad: Medicine; 1980: 190
    Google Scholar
  • 25 Toyoda Y, Naitoh Y, Miyamoto K et al. Leuco-cytosis and severe pain due to ureteral calculi. Hinyokika Kiyo 1988; 34: 1357-1361
    PubMedGoogle Scholar
  • 26 Trinchieri A, Coppi F, Montanari E et al. Increase in the prevalence of symptomatic upper urinary tract stones during the last ten years. Eur Urol 2000; 37: 23-25
    CrossrefPubMedGoogle Scholar
  • 27 Trinchieri A. Epidemiology of urolithiasis. Arch Ital Urol Androl 1996; 68: 203-249
    PubMedGoogle Scholar
  • 28 Valentao P, Fernandes E, Carvalho F et al. Hydroxyl radical and hypochlorous acid scavenging activity of small centaury (Centaurium erythraea) infusion. A comparative study with green tea (Camellia sinensis) . Phytomedicine 2003; 10: 517-522
    CrossrefPubMedGoogle Scholar
  • 29 Worcester EM, Coe FL. Clinical practice. Calcium kidney stones. N Engl J Med 2010; 363: 954-963
    CrossrefPubMedGoogle Scholar
  • 30 Yamahara J, Konoshima T, Sawada T, Fujimura H. Biologically active principles of crude drugs: pharmacological actions of Swertia japonica extracts, swertiamarine and gentianine. Yakugaku Zasshi 1978; 98: 1446-1451
    PubMedGoogle Scholar
  • 31 Yarnell E. Botanical medicines for the urinary tract. World J Urol 2002; 20: 285-293
    PubMedGoogle Scholar