Effect of Ailanthus altissima (Mill.) Swingle and Ailanthus excelsa Roxb. stem bark extracts on Streptozotocin Induced Diabetes

A Abd Elhleem Said; K Nabih Rashed; C Ho Kim

doi:10.1055/s-0031-1282758

Planta Medica, Table of Contents

Effect of Ailanthus altissima (Mill.) Swingle and Ailanthus excelsa Roxb. stem bark extracts on Streptozotocin Induced Diabetes

A Abd Elhleem Said ¹, K Nabih Rashed ¹, C Ho Kim ²

¹Department of Pharmacognosy, National Research Centre, Dokki, Cairo, Egypt
²Cheorl Ho-Kim, Department of Biochemistry, College of Oriental Medicine, Dongguk University, Kyungju, Korea

Abstract

The inhibitory effects of methanol (70%) extracts of Ailanthus altissima (Mill.) Swingle and Ailanthus excelsa Roxb. stem bark on streptozotocin (ST) – induced diabetes mellitus were studied using ST – treated diabetic model. When the effects of the extracts on ST-induced ATP/ADP ratio of islets were assayed, the extracts were effective in restoring of ATP/ADP ratio and when the islets (200/condition) were treated with ST (5 mM for 30 min.) and then the extracts were added to the ST-treated cells, the extracts concentration (200 µg/ml) showed increased insulin production in pancreatic islet cells.

Keywords: Ailanthus excelsa, Ailanthus altissima, stem bark, Antidiabetic activity