ABSTRACT
We sought to validate a proposed vaginal birth after cesarean (VBAC) prediction model
that includes variables available “at or close to delivery” and compare its accuracy
to one that only uses variables available at “entry to care.” We performed a retrospective
cohort study of term pregnant women with a vertex singleton gestation attempting a
trial of labor (TOL) after a single prior low transverse cesarean delivery. VBAC rates,
predicted using the “close to delivery” model, were partitioned into deciles. The
observed VBAC rate in each partition was compared with the predicted one. The accuracy
of the two models was compared using the receiver operating characteristics curve.
The predicted VBAC probability was higher in patients who had VBAC compared with those
who failed a TOL (median [interquartile range]: 74.9% [59.6 to 86.1] versus 48.6%
[35.4 to 66.7]; p < 0.001). The correlation between the observed and predicted VBAC rates was high
(r = 0.98; p < 0.001). In the subset of patients who had the complete set of variables available
for the two models (n = 490), the “close to delivery” model was more accurate. We validated the proposed
VBAC prediction model in an independent cohort. Incorporating information available
at delivery improves its accuracy.
KEYWORDS
Vaginal birth after cesarean - trial of labor - prediction model
REFERENCES
1 Hamilton B E, Martin J A, Ventura S J. Births: Preliminary Data for 2007. National
vital statistics reports. Vol. 57. No 12. Hyattsville, MD: National Center for Health
Statistics; Released March 18, 2009. Available at: http://www.cdc.gov/nchs/data/nvsr/nvsr57/nvsr57_12.pdf
2 Martin J A, Hamilton B E, Sutton P D et al.. Births: Final Data for 2006. National
Center for Health Statistics. January 7, 2009. Available at: http://www.cdc.gov/nchs/data/nvsr/nvsr57/nvsr57_07.pdf Accessed June 1, 2010
3
American College of Obstetricians and Gynecologists .
Vaginal birth after previous cesarean. ACOG Practice Bulletin No. 54.
Obstet Gynecol.
2004;
104
203-212
4
Landon M B, Leindecker S, Spong C Y National Institute of Child Health and Human Development
Maternal-Fetal Medicine Units Network et al.
The MFMU Cesarean Registry: factors affecting the success of trial of labor after
previous cesarean delivery.
Am J Obstet Gynecol.
2005;
193
(3 Pt 2)
1016-1023
5
Landon M B, Hauth J C, Leveno K J National Institute of Child Health and Human Development
Maternal-Fetal Medicine Units Network et al.
Maternal and perinatal outcomes associated with a trial of labor after prior cesarean
delivery.
N Engl J Med.
2004;
351
2581-2589
6 NIH Consensus Development Conference on Vaginal Birth after Cesarean: New Insights.
March 8–10, 2010. Bethesda, MD; Available at: http://consensus.nih.gov/2010/images/vbac/vbac_statement.pdf Accessed May 24, 2010
7
Grobman W A, Lai Y, Landon M B National Institute of Child Health and Human Development
(NICHD) Maternal-Fetal Medicine Units Network (MFMU) et al.
Development of a nomogram for prediction of vaginal birth after cesarean delivery.
Obstet Gynecol.
2007;
109
806-812
8
Grobman W A, Lai Y, Landon M B for the National Institute of Child Health and Human
Development Maternal-Fetal Medicine Units Network et al.
Does information available at admission for delivery improve prediction of vaginal
birth after cesarean?.
Am J Perinatol.
2009;
26
693-701
9
Costantine M M, Fox K, Byers B D et al..
Validation of the prediction model for success of vaginal birth after cesarean delivery.
Obstet Gynecol.
2009;
114
1029-1033
10
Zweig M H, Campbell G.
Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical
medicine.
Clin Chem.
1993;
39
561-577
11
Hanley J A, McNeil B J.
The meaning and use of the area under a receiver operating characteristic (ROC) curve.
Radiology.
1982;
143
29-36
12
Lasko T A, Bhagwat J G, Zou K H, Ohno-Machado L.
The use of receiver operating characteristic curves in biomedical informatics.
J Biomed Inform.
2005;
38
404-415
13
Lilliefors H W.
On the Kolmogorov-Smirnov test for normality with mean and variance unknown.
J Am Stat Assoc.
1967;
62
399-402
14
Rossi A C, D'Addario V.
Maternal morbidity following a trial of labor after cesarean section vs elective repeat
cesarean delivery: a systematic review with metaanalysis.
Am J Obstet Gynecol.
2008;
199
224-231
15
Grobman W A, Lai Y, Landon M B Eunice Kennedy Shriver National Institute of Child
Health and Human Development Maternal-Fetal Medicine Units Network et al.
Can a prediction model for vaginal birth after cesarean also predict the probability
of morbidity related to a trial of labor?.
Am J Obstet Gynecol.
2009;
200
56-e1–e6
Maged M CostantineM.D.
Assistant Professor, Department of Obstetrics and Gynecology, University of Texas
Medical Branch
301 University Boulevard, Galveston, TX 77555-0587
Email: mmcostan@utmb.edu