Thorac Cardiovasc Surg 2011; 59(4): 222-228
DOI: 10.1055/s-0030-1270959
Original Cardiovascular

© Georg Thieme Verlag KG Stuttgart · New York

The C-Port xV® Vascular Anastomosis System: Results from an Animal Trial

U. Kappert1 , A. Ouda1 , R. Virmani2 , D. Mettler3 , K. Matschke1 , S. Demertzis4 , 5
  • 1Department of Cardiac Surgery, Heart Center Dresden University Hospital, Dresden, Germany
  • 2CV Path Institute, Inc., Gaithersburg, Maryland, United States
  • 3Surgical Research Institute, University Hospital Bern Inselspital, Bern, Switzerland
  • 4Department of Cardiac Surgery, Cardiocentro Ticino, Lugano, Switzerland
  • 5Department of Cardiovascular Surgery, University Hospital Bern Inselspital, Bern, Switzerland
Further Information

Publication History

received Sept. 22, 2010 resubmitted March 7, 2011

accepted March 8, 2011

Publication Date:
25 March 2011 (online)

Abstract

Background: In this study, facilitated anastomosis using an anastomotic device was compared to conventional hand-sewn (HS) vascular anastomosis in an animal model. Methods: A pig carotid bypass model was employed. C-Port xV® (xV) and HS anastomoses were compared by evaluating intraoperative performance, midterm graft patency, and histology. Results: All animals survived; none developed early/late neurological deficits. Mean graft blood flow was comparable between groups (HS group: 161 ± 61 ml/min; xV group: 143 ± 44 ml/min). All anastomoses were patent at necropsy (at 111 ± 6 postoperative days). Histologically, no significant inflammation was found around the fasteners or in the vessel wall. Neointimal overgrowth on the lumen surface appeared organized and covered with endothelium. There was no adherence of fibrin, platelets, or inflammatory cells to the surface. The neointimal tissue appeared normal without any inflammation, hemorrhage, calcification, or necrosis. Conclusion: Facilitated vascular anastomosis using the xV anastomotic device is safe and effective in the pig carotid bypass model. Further studies should evaluate the efficacy of this device when used in confined spaces to define its potential role in minimally invasive procedures.

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Dr. Stefanos Demertzis

Department of Cardiac Surgery
Cardiocentro Ticino

Via Tesserete 48

6900 Lugano

Switzerland

Phone: +41 9 18 05 31 44

Fax: +41 9 18 05 31 48

Email: demertzis@cardiocentro.org

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