Thorac Cardiovasc Surg 2011; 59 - eP151
DOI: 10.1055/s-0030-1269361

Increased preoperative C-reactive protein contributes to perioperative myocardial injury

G Goerlach 1, C Wassmann 2, P Roth 1, A Böning 1
  • 1Universitätsklinik Gießen u. Marburg GmbH, Standort Gießen, Klinik f. Herz-, Kinderherz-u. Gefäßchirurgie, Gießen, Germany
  • 2UKGM GmbH, Standort Gießen, Anaesthesiologie u. operative Intensivmedizin, Gießen, Germany

Objectives: C-reactive protein (CRP) is known to be associated with an increased cardiovascular risk. In order to find out if an increased preoperative CRP contributes to perioperative myocardial injury in patients undergoing coronary artery bypass grafting (CABG) we investigated the correlation between CRP and parameters of myocardial injury.

Methods: In 129 patients undergoing elective CABG we analysed preoperative CRP and the level of TNI and CKMB 24h post surgery. The mean age was 65.2±9.4 years.

Patients with infection,rheumatic disease and a history of malignant disease were excluded.

Results: In 47 patients preoperative CRP was <1 (group 1) and in 82 >1 (group 2).

TNI was 5.59±9.30µg/l in group 1 and 22.43±29.73µg/l in group 2. CKMB measured 36.09± 36.43U/l in group1 and 73.54±71.32U/l in group2. The difference between both groups regarding the parameters of myocardial injury was significant (p<0.0005). The correlation between aortic clamping time and TNI was weak (0.170).

Conclusions: From our results we conclude that an increase of CRP before surgery is associated with an increase of perioperative myocardial injury.